YAP KOK SENG, IVAN

Designation/Title : Dr.
Department: Department Life Sciences
Tel: 03-2731 7474 
Fax: N/A
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Education and Training

PhD in Chemistry Imperial College London, UK 2005
BSc. (Hons) 1st Class in Pharmaceutical Sciences University of Greenwich, UK 2001
Diploma in Industrial Studies University of Greenwich, UK 2001

 

Research interests:

All aspects of metabonomics and chemometrics:

  • Human health, gut microbial-mammalian metabolic interactions, nutritional interventions, environmental toxicology, parasitology and diseases.
  • Large-scale epidemiological research in cardiovascular diseases and application of metabonomics in epidemiology


Research projects/grants:

  • Malaysian Ministry of Science, Technology and Innovation eScience Research Grant Scheme (2012 - 2015): Characterising Host-Parasite Metabolic Interaction of Toxoplasma gondii Infection in Murine Model: A System Biology Approach (Principal investigator; RM$234K)
  • Malaysian Ministry of Higher Education, Fundamental Research Grant Scheme (2012 - 2015): Functional role of p53 family proteins in cell metabolism (Principal investigator; RM$179K)
  • Malaysian Ministry of Higher Education, Fundamental Research Grant Scheme (2012 - 2014): Fast Analysis Of Wood Extractives For Authentication Of Plant Species (Co-investigator; RM$70K)
  • International Medical University (Malaysia) Internal Fund (2012): Functional role of p63 in cell metabolism (Principal investigator; RM$20K)
  • Malaysian Ministry of Science, Technology & Innovation, Nanotechnology Research Grant (2011 – 2014): Systemic delivery of siRNA-based therapeutics using functionalized single-walled carbon nanotubes (International Medical University, Co-investigator; RM$370K)
  • Australian Rotary Health: Autism Grant (August 2009 – July 2010): Investigating the link between gastrointestinal disturbance and aetiology of autism (Imperial College, Co-investigator; A$35,000)

 

Supervision of Postgraduates (MSc/PhD)
(Last 5 years – 2008-2012)

PhD Project:

  • Metabolic approaches towards understanding of host-pathogen interaction in Cryptococcus neoformans (2012-present) – Mr Liew Kah Leong (Taylor’s University; Co-supervisor).
  • Application of NMR & UPLC-MS in metabonomics (2006-2009) – Dr. Vinothini Sivarajah
  • Effects of Pro-, Pre- & Symbiotic in mammalian-microbe co-metabolism (2007-2011) – Dr. Claire Merrifield

MRes Project:

  • Understanding the metabolic bases of Autistic Spectrum Disorder using NMR-based metabonomic (2008-2009) – Mr. Abdullah Alkandari

B.Sc. Project:

  • Functional role of p63 in cell metabolism (2012-ongoing) – Mr. Dhassareth Manickam (IMU)
  • Discovery of biomarkers for temporomandibular disorders through salivary metabolomic profiling (2012-ongoing) – Marcus Lee Chee Yen (IMU)


Professional affiliations:

  • Member of the Royal Society of Chemistry (347839)
  • Member of the British Society for Parasitology (05601): 2008 – 2010; 2012
  • Member of the National Autistic Society (UK) (66413)

Academic Awards:

  • Overseas Research Scholarship 2002 - 2005
  • E de Barry Barnett Prize (Chemical Sciences) for Outstanding Achievement 2001
  • British Scholarship Scheme 1998
  • H-index factor (Web of Science)
    13 (Total peer-reviewed publications: 18; Average citations per item: 40; Total cites without self-citations: 777 (ISI Web of Science July 2012)

     

Recent publications
(last 5 years – 2008 -2012)

  • Martin FP, Wang Y, Sprenger N, Yap IKS, Lundstedt T, Lek P, Rezzi S, Ramadan Z, van Bladeren P, Fay LB, Kochhar S, Lindon JC, Holmes E, Nicholson JK. ‘Probiotic modulation of symbiotic gut microbial–host metabolic interactions in a humanized microbiome mouse model’ Mol. Syst. Biol. 2008, 4, 157.
  • Holmes E, Loo RL, Stamler J, Bictash M, Yap IKS, Chan Q, Ebbels T, De Iorio M, Brown IJ, Veselkov K, Daviglus M, Kesteloot H, Ueshima H, Zhao L, Nicholson JK, Elliott P. ‘Diversity of Urinary Metabolic Phenotypes across Human Populations and Associations with Diet and Blood Pressure’ Nature 2008, 453, 396-400.
  • Martin FP, Wang Y, Sprenger N, Yap IKS, Rezzi S, Ramadan Z, Pere´-Trepat E, Rochat F, Cherbut C, van Bladeren P, Fay LB, Kochhar S, Lindon JC, Holmes E, Nicholson JK. ‘Top-down systems biology integration of conditional prebiotic modulated transgenomic interactions in a humanized microbiome mouse model’ Mol. Syst. Biol. 2008, 4, 205.
  • Yap IKS, Li JV, Saric J, Martin FP, Davies H, Wang Y, Wilson ID, Nicholson JK, Utzinger J, Marchesi JR, Holmes E. ‘Metabonomic and Microbiological Analysis of the Dynamic Effect of Vancomycin-induced Gut Microbiota Modification in Mice’ J. Proteome Res. 2008, 7, 3718-3728.
  • Martin FP, Sprenger N, Yap IKS, Wang Y, Bibiloni R, Rochat F, Rezzi S, Cherbut C, Kochhar S, Lindon J, Holmes E, Nicholson J. ‘Panorganismal gut microbiome-host metabolic crosstalk’ J. Proteome Res. 2009, 8, 2090-2105.
  • Martin FP, Wang Y, Yap IKS, Sprenger N, Lindon JC, Rezzi S, Kochhar S, Elaine Holmes E, Nicholson JK ‘Topographical variation in murine intestinal metabolic profiles in relation to microbiome speciation and functional ecological activity’ J. Proteome Res. 2009, 8, 3464-6474.
  • Saric J, Li JV, Wang Y, Keiser J, Veselkov K, Dirnhofer S, Yap IKS, Nicholson JK, Holmes E, Utzinger J. ‘Panorganismal metabolic response modeling of an experimental Echinostoma caproni infection in the mouse.’ J Proteome Res. 2009, 8, 3899-3911.
  • Loo RL, Coen M, Ebbels T, Cloarec O, Maibaum E, Bictash M, Yap I, Elliott P, Stamler J, Nicholson JK, Holmes E; for the INTERMAP Research Group. ‘Metabolic Profiling and Population Screening of Analgesic Usage in Nuclear Magnetic Resonance Spectroscopy-Based Large-Scale Epidemiologic Studies.’ Anal. Chem. 2009, 81, 5119-5129.
  • Bictash M, Ebbels TM, Chan Q, Loo RL, Yap IKS, Brown IJ, de Iorio M, Daviglus ML, Holmes E, Stamler J, Nicholson JK, Elliott P. ‘Opening up the "Black Box": Metabolic phenotyping and metabolome-wide association studies in epidemiology.’ J. Clin. Epidemiol. 2010, 63, 970-979.
  • Yap IKS, Angley M, Veselkov K, Martin FP, Holmes E, Lindon JC, Nicholson JK. ‘Urinary Metabolic Phenotyping Differentiates Children with Autism from Their Unaffected Siblings and Age-Matched Controls’ J. Proteome Res. 2010, 9, 2996-3004.
  • Yap IKS, Brown IJ, Chan Q, Wijeyesekera A, Garcia-Perez I, Bictash M, Loo RL, Chadeau-Hyam M, Ebbels TM, de Iorio M, Maibaum E, Zhao L, Kesteloot H, Daviglus ML, Stamler J, Nicholson JK, Elliott P, Holmes E. ‘Metabolome-Wide Association Study Identifies Multiple Biomarkers that Discriminate North and South Chinese Populations at Differing Risks of Cardiovascular Disease: INTERMAP Study.’ J. Proteome Res. 2010, 9, 6647-6654.
  • Kinross JM, Alkhamesi N, Barton RH, Silk DB, Yap IKS, Darzi AW, Holmes E, Nicholson JK. ‘Global metabolic phenotyping in an experimental laparotomy model of surgical trauma.’ J. Proteome Res. 2010, 10, 277-287. (Epub).
  • Louise Thomas E, Parkinson JR, Hyde MJ, Yap IKS, Holmes E, Doré CJ, Bell JD, Modi N. ‘Aberrant adiposity and ectopic lipid deposition characterise the adult phenotype of the preterm infant.’ Pediatr. Res. 2011, 70, 507-12.
  • Wijeyesekera A, Clarke P, Bictash M, Brown IJ, Fidock M, Ryckmans T, Yap IKS, Chan Q, Stamler J, Elliott P, Holmes E, Nicholson JK. ‘Quantitative UPLC-MS/MS analysis of the gut microbial co-metabolites phenylacetylglutamine, 4-cresyl sulphate and hippurate in human urine: INTERMAP Study.’ Anal. Methods. 2012, 4, 65-72.
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