TAN ENG LAI

Designation/Title : Associate Professor
Contact Information : Life Sciences, School of Pharmacy,
Tel: 03-27317466 ;
Fax:

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Nationality : Malaysia

 

Education and Training

PhD University of Malaya,
Field of Study: Cancer Biology and Immunology.
2004
M.Biotechnology University of Malaya
Field of Study: Algal Biotechnology.
2000
BSc
Murdoch University,
1996

Work Experience

  • 2005-2006: Postdoctoral Fellow, Institute of Advanced Studies, University Malaya, Kuala Lumpur.
  • 2006-Present: International Medical University, Kuala Lumpur.

 

 

Research interests:

  • Nasopharyngeal carcinoma
  • Cancer Stem Cells
  • Bioactive molecules and drug delivery

 

Research projects/grants:

  • Project Title: Identification Of Self-Renewal And Developmental Pathways In Nasopharyngeal Carcinoma Cancer Stem Cells Through Gene And MicroRNA Expression Profiling and Functional Studies 
    Funded by: Ministry of Higher Education – FRGS, Year 2013
    Amount: RM124,000 
    Principal Researcher: Dr Tan Eng Lai
  • Project Title: Epstein-Barr virus Latent Membrane Protein 1: Its Roles in Invasion and Metastasis in Nasopharyngeal Carcinoma
    Funded by: National Cancer Council (MAKNA), Year 2006
    Amount: RM25,000
    Principal Researcher: Dr Tan Eng Lai
  • Project Title: Nasopharyngeal Carcinoma: Roles of Epstein-Barr virus Latent Proteins in Invasion and Metastasis
    Funded by: Ministry of Health Malaysia. Year 2007.
    Amount: RM290,800
    Principal Researcher: Dr Tan Eng Lai
  • Project Title: Potential anti-Alzheimer’s activity of brown algae metabolites.
    Funded by: MOSTI
    Amount: RM245,000
    Principal Researcher: Dr Gan Sook Yee
  • Project Title: Systemic Delivery of siRNA-Based    Therapeutics using Functionalized Single-Walled Carbon Nanotubes (SWNTs).
    Funded by: MOSTI Nano
    FundAmount: RM329,800
    Principal Researcher: AP Dr Leong Chee Onn
  • Project Title: Use of Algae in Genotoxicity Assessment of Marine Ecosystems
    Funded by: MOSTI E-science
    FundAmount: RM276,500
    Principal Researcher: Prof Dr Chu Wan Loy
  • Project Title: Expression Profiling of Micro RNA in Nasopharyngeal Carcinoma in Response to Interleukins and Tranforming Growth Factor.
    Funded by: MOHE FRGS
    FundAmount: RM44,800
    Principal Researcher: Dr Gan Sook Yee
  • Project Title: Reversal of age-related hyposalivation by upregulation of salivary gland aquaporins.
    Funded by: MOHE ERGS, Year 2013
    Amount: RM141,000
    Principal Researcher: Prof Frederick Smales
  • Project Title: Potential anti-Alzheimer’s activity of brown algae metabolites.
    Funded by: MOSTI, Year 2012
    Amount: RM245,000
    Principal Researcher: Dr Gan Sook Yee
  • Project Title: Expression Profiling of Micro RNA in Nasopharyngeal Carcinoma in Response to Interleukins and Tranforming Growth Factor.
    Funded by: MOHE FRGS, Year 2010
    Amount: RM44,800
    Principal Researcher: Dr Gan Sook Yee

 

Supervision of Postgraduates (MSc/PhD)
(Last 5 years – 2008-2012)

Main-supervisor of the following students.

  • Ms Tsen Min Tse. PhD Student. Registered in 2011. International Medical University.
  • Mr Wong Chee Yin. PhD Student. Registered in 2010. International Medical University.
  • Ms Michelle Chew Mei Siew. MSc Student. Project completed in 2011. International Medical University. Awaiting convocation.
  • Ms Sarah Yuen. B.Med.Sci Student. International Medical University. Graduated in 2009.
  • Ms Poh Yi Wen. B.Med.Sci Student. Registered in 2011.



Co-supervisor of the following students.

  • Mr Kenneth Chew Yee Choy. PhD Student. Registered in 2009. Monash University, Sunway Campus. Main-supervisor: AP Dr Chow Sek Yuen.
  • Mr Lim Wei Meng. PhD Student. Registered 2010. International Medical University. Main-supervisor: Dr PS Rajinikanth.
  • Mr Tan Boon Keat. PhD Student. Registered in 2007. International Medical University. Main-supervisor: Prof Chu Wan Loy.
  • Ms Catherine Lee Ting Wei. MSc Student. Registered in 2010. Main-supervisor: Dr Gan Sook Yee.
  • Mr Tan Boon Shing. MSc Student. Registered in 2009. International Medical University. Main-supervisor. Dr Leong Chee Onn.

 

Professional affiliations:

  • ....

 

Academic Awards:

  • ....

Publications

Indexed Journals

  • Tiong KH, Mohammed Yunus NA, Yiap BC, Tan EL, Ismail R, et al. Inhibitory potency of 8-methoxypsoralen on cytochrome P450 2A6 (CYP2A6) allelic variants CYP2A6*15, CYP2A6*16, CYP2A6*21 and CYP2A6*22: Differential susceptibility due to different sequence locations of the mutations. PLoS ONE, 2014; 9(1): e86230. DOI:10.1371/journal.pone.0086230. (SCI IF: 3.675; H-index: 101; Tier: Q1).
  • Chee-Yin Wong, Eng-Lai Tan and Soon-Keng Cheong . In vitro differentiation of mesenchymal stem cells into mesangial cells when co-cultured with injured mesangial cells. Cell Biology International, 2014 (e-publication). IF:1.635
  • TW Lee, EL Tan and SY Gan. 2013. The Effect of Cytokines on MicroRNA Expression in TW01 Nasopharyngeal Carcinoma Cells. British Journal of Medicine and Medical Research, 3(3): 543-554.
  • Yew Beng Kang, Pichika R Mallikarjuna, Davamani A Fabian, Adinarayana Gorajana, Chooi Ling Lim, Eng Lai Tan. 2013. Bioactive molecules: current trends in discovery, synthesis, delivery and testing. IeJSME 2013:7 (Suppl. 1): 32-46
  • YW Poh, SY Gan and EL Tan. 2012. Effects Of Il-6, Il-10 And Tgf-Β On The Expression Of Survivin And Apoptosis In Nasopharyngeal Carcinoma Tw01 Cells. Experimental Oncology, 34(2):85-89.
  • Chew MMS, Gan SY, Khoo ASB, Tan EL. 2010. Interleukins, Laminin and Epstein - Barr virus Latent Membrane Protein 1 (EBV LMP1) Promote Metastatic Phenotype in Nasopharyngeal Carcinoma. BMC Cancer, 10:574.
  • Sin-Loong Ho, Eng Lai Tan, Chook Kook Sam and Khean-Lee Goh. 2010. Clarithromycin resistance and point mutations in the 23S rRNA gene in Helicobacter pylori isolates from Malaysia. Journal of Digestive Disease 11(2): 101-105.

 

Academic and Research Administration

  • Coordinate the following modules: B.Pharm-Research Methodology
  • Coordinate the following semester: B.Pharm Semester 7

1. Head of Centre for Bioactive Molecules and Drug Discovery and Delivery - responsible for coordinating research activities which include preparation of research proposals and presentations and establishing guidelines for the conduct of research. Part of my duties is to ensure that academic staff receives sufficient support in research. This involves identifying expertise gaps and planning for suitable training workshops.

The remits of the working group are as follow:

  • To formulate guidelines governing the various processes and conduct of undergraduate research projects.
  • To foster collaborative research between IMU and external institutions.
  • To provide support to staff in areas of research training and securing of research funding.
  • To track the involvement ofstaff in research and to monitor their research activities.
  • To offer assistance and advices to staffs in their research proposals.

2. Coordinator of British Council Prime Minister Initiatives 2 Student Mobility Programme - The British Council PMI2 programme funds students from the United Kingdom for short-term overseas placements with the purpose of providing an international dimension in their education. The successful bidding for this funding in 2009 resulted in the inception of a student mobility programme between the University of Strathclyde and IMU in 2010. This had enabled the placement of five undergraduate pharmacy students from Strathclyde in IMU for a period of six weeks in 2010 to conduct a short-term research project. Another five students are expected to spend similar period of time in IMU beginning July 2011.

3. Organising Conferences and Workshops - Organising Chairman for the following workshops that are meant to support IMU staff in research. These workshops were also opened to external participants.

 

  • Academy of Sciences Malaysia and Dr Ranjeet Bhagwan Singh National Fellowship Workshop on “Human Embryonic Stem Cell: Culture and Maintenance”. 14th-15th Dec 2009. International Medical University.
  • Scientific Writing for the Medical, Health and Life Sciences by Prof Brian Furman. 2010. International Medical University.16th Aug 2010.
  • Workshop on Communicating Research Findings to A Scientific Audience by Prof Brian Furman. 10th Feb 2011.
  • Workshop on Grant Writing Skills by Prof Brian Furman. 2011, 2012 and 2013.

 

4. Secretary of IMU Research and Ethics Committee

5. External Affairs

  • a panel member of the Biotechnology Division, Ministry of Science, Technology and Innovation (MOSTI) the function of which is to evaluate new research proposals and progress report presentations.
  • a member of the following international scientific editorial panels:
    - Biotechnology and Applied Biochemistry. Published by Portland Press Ltd on behalf of the International Union of Biochemistry and Molecular Biology (IUBMB).
    - Pathology. Published by Taylor and Francis on behalf of The Journal of the Royal College of Pathologists of Australasia.
    - Stem Cell. Published by Wiley.
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