RADHAKRISHNAN, AMMU KUTTY G.K.

Designation/Title : Professor
Department: Pathology Division, School of Medicine
Tel: +60327317205
Fax: +60386567229
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

 

 




Education and Training

PhD
University of Cambridge, United Kingdom 1994
MSc
University of Malaya, Malaysia 1990
BSc (Hons) University of Malaya, Malaysia 1987

 

Research interests:

  • Immunotherapeutics
  • Tumour immunology
  • Natural bioactive compounds with immunomodulatory effects
  • Genomics
  • Epigenetics

 

Research projects/grants:
(Listing of latest 15 projects)

  • PRINCIPLE INVESTIGATOR
    • DNA Methylation Patterns Induced By Tocotrienols In The CD4+ T-Lymphocytes Isolated From A Mouse Model of Breast Cancer [IMU R 113-2013] funded by FRGS (MoE)
    • The Effect of Tocotrienols in an Epigenetic Landscape of MCF-7 and MDA-231 Human Breast Cancer Cells [IMU R 095-2012] funded by MPOB
    • The elucidation of molecular targets and pathways regulated by tocotrienols (delta and gamma) and ß-carotene in human chronic myelogenous leukaemia cell line (K562) in vitro. [IMU R 102-2012] funded by MPOB
    • Elucidation of molecular targets and pathways regulated by tocotrienols in murine breast cancer cells. [IMU R 081-2012] funded by IMU and MPOB
    • Gene expression profiling in the modulatory effect of human bone marrow-derived mesenchymal stem cells in a chronic myeloid leukaemia (K562) cell line [BMS I-01/2011(10)] funded by IMU
    • Alteration in Gene Expression Profile of Mice Prenatally Exposed to Bisphenol A at Low Doses.  [IMU 236-2011] funded by IMU
    • A study of the mechanisms of neuroprotective effect of vitamin E on oxidative stress induced dopaminergic neuronal dysfunction in rat model of Parkinson’s disease [IMU 210-2010] funded by IMU
    • Molecular mechanisms of tocotrienols adjuvanted dendritic cell using a mouse model of breast cancer.  [IMU 232-2011] funded by IMU and MPOB
    • The Mechanism of Tocotrienol Induced Cell Death in Leukaemic Cells In Vitro.  [IMU 231-2011] funded by IMU
    • Molecular Mechanisms of Antioxidant Effects of Quercetin and its Glycoside Derivatives against 6-hydroxy dopamine (6-OHDA)-Induced Cytotoxic Damage in PC-12 Neuronal cells [IMU 230-2011] funded by IMU
    • Compare the therapeutic efficacy of gamma-tocotrienol against delta-tocotrienol supplementation in a collagen-induced arthritis rat model.  [BMS I02-2010 (13)] funded by IMU
    • Anti-inflammatory effects of standardised plant extracts from Nephelium lappaceum using cell-based assay and experimental model. [IMU 211-2010] funded by IMU and MoH
    • Synergistic effect of tocotrienols and other pytonutrients from palm oil in a cell-based system [IMU181-2009] funded by IMU and MPOB
    • Therapeutic effects of ostrich oil on arthritis in rat model.   [IMU 165-2008] funded by IMU
    • The Effect of Ostrich Oil on Arthritis in Animal Model [IMU R 027-2007] funded by MoH
    • Evaluate the efficacy of gamma-delta rich tocotrienol supplementation against collagen-induced arthritis in rat.  [BMS I02-2009(04)] funded by IMU
    • Diagnostic and Clinical Value of Rheumatoid Factor (RF) Isotypes and Anti-cyclic Citrullinated Peptides (Anti-ccp) in Rheumatoid Arthritis (RA) Patients.  [BMS I02-2008(09)] funded by IMU
    • Effect of combined administration of co-enzyme Q10 and Levodopa on striatal tyrosine hydroxylase expression and antioxidant biomarkers in rat model of Parkinson’s disease [funded by IMU]
    • Tocotrienols as an adjuvant in Developing Cancer Vaccines.  [IMU 142-2007] funded by IMU and MPOB
    • To investigate the Therapeutic Effect of Recombinant Mouse cytokines (e.g.IL-18, IL-15) in Murine Breast Cancer Model. [IMU 211-2006] funded by eScience, MOSTI
    • Identification of Receptors for Tocotrienol Using Computer Modelling Systems.  [IMU 162-2008] funded by IMU and MPOB
    • Molecular Mechanism of Immune Regulation with Tocotrienol Supplementation.  [IMU 131-2007] funded by IMU and MPOB
    • To Investigate the Therapeutic Effect of Recombinant Mouse Cytokines in Murine Breast Cancer Model.  [funded by IMU]
    • Protective antioxidant effect of methanolic extracts of Spirulina against Oxidant-Induced Cell Death. [funded by IMU]
    • Effect of spirulina supplementation on immune response to tetanus toxoid vaccination in mouse model.  [funded by IMU]
    • Association of Interleukin-13 (IL-13) Gene Polymorphisms with Plasma IgE Levels and IL-13 Production in Malaysian Asthmatics: A Pilot study.  [funded by IMU]
    • The effect of vitamin E Supplementation on Immune Response to Tetanus Toxoid Immunisation in mouse model.  [funded by IMU]
    • The effect of vitamin E Supplementation on Immune Response to Tetanus Toxoid Immunisation in Normal Human Volunteers.  [funded by IMU]
    • Comparison of the relationship between the expression of IL-12 Beta-2 receptor (IL-12?2) and CD30 on surface of T-lymphocytes and disease manifestation in systemic lupus erythemathosus (SLE) and rheumatoid arthritis (RA) patients from Hospital Seremban. [funded by IMU]
    • Relationship between TH1 and TH2 cytokines and the clinical manifestation of autoimmune diseases in systemic lupus erythemathosus (SLE) and rheumatoid arthritis (RA) patients from Hospital Seremban – a pilot study.  [funded by IMU]
    • Relationship between Interleukin-10 promoter region polymorphisms and clinical manifestation of systemic lupus erythemathosus. [funded by IMU]
    • Relationship between Interleukin-10 promoter region polymorphisms and clinical manifestation of rheumatic arthritis (RA).  [funded by IMU]
    • Clinical trial:  Compatibility of Omnican Pen Needles with Humapen/BD Pen,Novopen. [funded by B. Braun]
    • Cytokines and SLE.  [funded by IMU]
  • CO-INVESTIGATOR
    • Immunomodulatory Effects of Tocotrienol and Spirulina on Tumourigenesis using A Mouse Model of Breast Cancer.[funded by IMU]
    • The study of anti-tumour effect of an oral administration of curcumin infused red palm oil on BALB/c mouse breast cancer model [BMS I-01/2011(13)] funded by IMU
    • Anti-hyperglycemic potential of Nephelium lappaceum purified fractions; evidence from cell-based assays and experimental animal model.  [IMU R060 2010] funded by eScience, MOSTI
    • Efficacy of Mesenchymal Stem Cells Transduced with Interleukin-12 or/and Interleukin-18 against Breast Cancer Cells [funded by IMU]
    • Elucidating the role of T-regulatory cells in regulating immune response in a murine breast cancer model funded by TORAY
    • The Effect of Oral Supplementation of Probiotics on Immune Responses to Tetanus Toxoid vaccination in Young Mice.  [IMU R038-2008] funded by TORAY
    • Effect of Bovine Colostrum on Exercise and Immune Modulation.  [IMU R037-2008] funded by SmartNaco
    • Nutraceutical Development from Local Plant Extracts Nephelium lappaceum (Rambutan) and Syzygium maingayi (Jambu Merah) with Significantly High Anti-Oxidant Activity. [IMU R024-2007]
    • The anti-proliferative, antioxidant and anti-mutagenic activities of the fractionated extracts of Pereksia bleo (Kunth) DC [funded by IMU]
    • Effect of Algal and Synthetic Astaxanthin on the Proliferation of Colorectal Cancer Cells. [funded by IMU]
    • Antioxidant and Cytotoxic Effects of Fractions and Isolated Compounds of Anogeissus latifolia in vitro in Epithelial Cells from Human Breast Cancer Cell Lines. [funded by IMU]
    • The Predictive Value of single Nucleotide Polymorphism (SNP) of the Human Tumor Necrosis Factor-alpha (TNF-?) and Interleukin-10 (IL-10) in Human Gestational Diabetes.  [funded by IMU]
    • Protective antioxidant effect of seaweed extracts against oxidant-induced cell death.  [funded by IMU]
    • Protective antioxidant effect of aqueous extracts of Spirulina against Oxidant-Induced cell death.  [funded by IMU]
    • Study of antioxidant and cytotoxic effects of Artemisia pallens.  [funded by IMU]
    • Molecular Analysis of Selected Genes among Malaysia Asthmatics – relationship between the Polymorphisms of IL-4 and Il-10 Promoter Region and the Inflammatory Markers, IL-4, IgE, in Malaysian Asthmatics.  [funded by IMU]
    • Clinical Trial:  Mechanistic studies to evaluate the inhibitory effects of tocotrienols and carotenes in hormone dependent cancers.  [funded by IMU & MPOB]
    • Study of antioxidant and cytotoxic effects of Embelia ribes on cell lines.  [funded by IMU]
    • Anti-cancer activities of crude methanolic and water extracts of Pereskia sacharosa via apoptosis in mammary cancer cell lines.  [funded by IMU]
    • Evaluating the potential anti-proliferative effect of Dsn 1p (yeast origin) expression in CHO and MCF cell lines. [funded by IMU]
    • p53 and p73 as molecular markers of growth and progression in carcinoma cervix.  [funded by IMU]
    • The protective anti-oxidative effect of extracts from local medicinal plants (Mangifera indica and Nephelium lappaceum ) to limit cell death from oxidant-induced apoptosis in cultured cells.  [funded by IMU]
    • To Study the Relationship Between Single Nucleotide Polymorphisms at position -1082 in the Interleukin-10 promoter Region with Clinical Manifestation of Rheumatoid Arthritis in Patients from Seremban Hospital.  [funded by IMU]
    • To Study the Relationship Between Single Nucleotide Polymorphisms at position -1082 in the Interleukin-10 promoter Region with Clinical Manifestation of Rheumatoid Arthritis in Patients from Seremban Hospital.  [funded by IMU]
    • The effect of tocotrienol vitamin E (tocotrienol and tocopherol) on immune modulation in normal human volunteers.  [funded by IMU and MPOB]
    • Relationship between Interleukin-10 promoter region polymorphisms and clinical manifestation of asthma.  [funded by IMU]
    • Development of dendritic cell vaccines for mouse breast cancers.  [funded by IRPA, MOSTI]
    • Formulation of anti-oxidant Nutraceuticals from Plant Extracts (e.g. Phyllanthus niruri, Azadirachta indica, Morinda Citrifolia and Murraya koennigi) [funded by IRPA, MOSTI]
    • Changes in the immune status of nude mice with breast cancers that are supplemented with palm carotenes and tocotrienols.  [funded by MPOB]
    • Interleukin-12 Receptor ?2 (IL-12R ?2) subunit expression in Human Systemic Lupus Erythematosus (SLE) and its relationship to TH1 and TH2 cells.  [funded by IRPA, MOSTI]

 

Supervision of Postgraduates (MSc/PhD)
(Last 5 years – 2010-2014)

SUPERVISION OF POST-GRADUATE STUDENTS

MAIN SUPERVISOR (PhD)

  • Elucidating the effects of gamma-tocotrienol (?-T3 supplementation on the ratio of T-helper: T-regulatory cells in a syngeneic mouse model of breast cancer.  (Shonia Subramaniam; Start: April 2014)
  • Alteration in Gene Expression Profile of Mice Prenatally Exposed to Bisphenol A at Low Doses.  (Shantakumari Rajan; Start: Dec 2010-2015)
  • A study of the mechanisms of neuroprotective effect of vitamin E on oxidative stress induced dopaminergic neuronal dysfunction in rat model of Parkinson’s disease:  (Mangala Kumari; Start: Feb 2010/part-time)
  • Therapeutic effects of ostrich oil on arthritis in rat model: (Muniswaran Sivanathan; Start: 2008)
  • Molecular mechanisms of tocotrienols adjuvanted dendritic cell using a mouse model of breast cancer:  (Sitti Rahmah; 2010-2013)
  • Molecular mechanism of immune regulation with tocotrienol supplementation: (Kanga Rani Selvaduray; 2008-2012)

CO-SUPERVISOR (PhD)

  • To elucidate the molecular mechanisms underlying the pathogenesis of ineffective erythropoiesis in ß-thalassemia using a cell-based model.  (Afshan Sumera; Start: March 2014/part-time)
  • Elucidating the epigenetic events and proteins regulated by tocotrienols in human breast cancer cells. (Premdass Ramdas; Start: Jan 2013)
  • Non-polymeric nanoparticle: a novel delivery system for the treatment of breast cancer (Usha Sundralingam; Start: 2012)
  • Immunomodulatory Effects of Tocotrienol and Spirulina on Tumourigenesis in Breast Cancer (Hemavathy Subramaniam; Start Dec 2011)
  • Identification of New Molecular Targets for Treatment of Basal- Like Breast Cancers.  (Tiong Kai Hung; 2010-2012)
  • Efficacy of Mesenchymal Stem Cells Tranduced with Interleukin-12 or/and Interleukin-18 against Breast Cancer Cells.  (Yap Fei Ling; 2006-2012)
  • Effect of Bovine Colostrum Supplementation on Exercise and Immune Modulation.  (Mahenderan Appukutty; 2006 to 2010)
  • The Predictive Value of single Nucleotide Polymorphism (SNP) of the Human Tumor Necrosis Factor-alpha (TNF-?) and Interleukin-10 (IL-10) in Human Gestational Diabetes.  (Shabnam Montazeri; 2006 to 2010)

MAIN SUPERVISOR (MSc)

  • DNA methylation patterns induced by tocotrienols in the CD4+ T-lymphocytes isolated from a mouse model of breast cancer (Jeya Seela a/p Anandha Rao; Start: Mac 2014)
  • Elucidation of molecular targets and pathways regulated by tocotrienols and carotenes in K562 human leukemic cells. (Haema Ng: 2012-2015)
  • Elucidation of molecular targets and pathways regulated by tocotrienols in murine breast cancer cells. (Tan Goi Chuan; Start Oct 2011)
  • Molecular mechanism of antioxidant effects of quercetin glycoside derivatives Against 6-Hydroxydopamine (6-OHDA) -induced cytotoxic damage in PC-12 neuronal cells. (Kasturi Bai Magalingam;(Start: 2010-2014/part-time)
  • Anti-inflammatory effects of standardised plant extracts from Nephelium lappaceum using cell-based assay and experimental model. (Shashi Kumar; Start: 2009-2013)
  • Synergistic effect of tocotrienols and other pytonutrients from palm oil in a cell-based system. (Radhika Loganathan; 2008 to 2011)
  • Identification of receptors for tocotrienol using computer modelling systems. (Premdass Ramdas; 2007 to 2010)
  • To investigate the therapeutic effect of recombinant mouse cytokines (e.g.IL-18, IL-15) in murine breast cancer model. (Shalini Sree Kumar; 2006 to 2010)

CO-SUPERVISOR (MSc)

  • Elucidating the roles of T-Helper and T-Regulatory Cells in Sarcoma Patients (Sarmini Munusamy; Start : Feb 2014)

 

Professional affiliations:

  • Fellow Cambridge Commonwealth Trust
  • Fellow Cambridge Philosophical Society
  • The Cambridge Society
  • Oxford-Cambridge Society of Malaysia
  • Malaysian Genetics Society
  • Laboratory Animal Science Association of Malaysia
  • Nutrition Society of Malaysia

 

Academic Awards:

  • Achievement Award for Research: (Individual Category -Second Place) from the International Medical University, April 2014
  • Achievement Award: Special (Noteworthy) Award for Commitment in Cross-Teaching (Pathology Team) from the International Medical University, Mac 2012
  • TORAY MSTF Research Grant Award (Co-recipient): Awarded by the Malaysian Science Foundation Science Technology Fund (MSTF) Sept 2009
  • SIIF Gold Prize: Invention titled “Chemflore: a potential novel proapoptotic anticancer agent” at the Seoul International Invention Fair (SIIF) 2008, Seoul, Korea (11-15 December, 2008)
  • ITEX Silver Medal: Invention titled “ Chemflore: A Potential Novel Proapoptotic Anticancer Agent” at the 19th International Invention, Innovation & Technology Exhibition (ITEX) 2008, Kuala Lumpur, Malaysia (9-11 May 2008)
  • Merit Award: Paper entitled “Application of Tocotrienols as an adjuvant in developing cancer vaccines” in the poster competition in conjunction with the International Palm Oil Congress - PIPOC 2007 (28-30 August 2007)
  • ITEX Silver Medal: Invention titled “ Tocotrienols as adjuvants in developing cancer vaccines” at the 18th International Invention, Innovation & Technology Exhibition ITEX 2007, Kuala Lumpur, Malaysia (18-20 May 2007)
  • TORAY MSTF Research Grant Award (Co-recipient): Awarded by the Malaysian Science Foundation Science Technology Fund (MSTF) Sept 2005
  • Best Poster Presentation Prize (Human Genetics Category): Project entitled “The Over-Expression of a Novel Gene Following Tocotrienol Supplementation of Human Cancer Cells is Absent in Cells Supplemented with Tocopherols”. Awarded at the 6th National Congress on Genetics, Kuala Lumpur (2-14 May, 2005)
  • Second Prize Winner (Poster Lab category): Project entitled “Comparison of the Ability of cryopreserved and fresh dendritic cells (DC) to inhibit tumour growth using a murine breast cancer model”. Awarded during the Minggu Penyelidikan Ke VI, Fakulti Perubatan, Universiti Kebangsaan Malaysia. (19-24 July 2004)
  • Bronze Medal (Research): Project titled “Perbandingan Keupayaan Antara Sel Dendritik (DC) Segar and yang Dikrioawtekan untuk Merencat Pertumbuhan Tumor dengan menggunakan Model Barah Payudara Tikus”. Awarded at the Ekspo Penyelidikan and Innovasi 2004, organised by the Universiti Kebangasaan Malaysia (15-18 July 2004)
  • Achievement Award for Outstanding Individual Achievement (First Category Award for Outstanding Achievements): Awarded by the International Medical University during the Recognition Award 2003 Annual Awards (5th December 2003)
  • Achievement Award for Outstanding Individual Achievement (Third Category Award for Research): Awarded by the International Medical University during the Recognition Award 2003 Annual Awards (5th December 2003)
  • Certificate of Merit: Outstanding leadership performance during the Leadership 21 (L21) Programme - Awarded by the International Medical University on 13th September 2003.
  • Lundgren Award: Awarded by the Cambridge University Board of Graduate Studies in Jan 1993.
  • Research Fellowship: Awarded by the Cambridge Philosophical Society in Oct 1992.
  • Overseas Research Scholarship (ORS) Award: Awarded by the ORS (UK) (Oct. 1989 - Sept. 1993)
  • Shell/Cambridge Commonwealth Trust Scholarship: Awarded by the Cambridge Commonwealth Trust (Oct. 1989 - Sept. 1993)
  • Research Fellowship: Awarded by University of Malaya (Dec 1987- Aug 1989)
  • University of Malaya Book Prize: Awarded for Final Year Results by the University of Malaya in Aug. 1987

 

Recent publications
(last 5 years – 2010 -2014)

2010

  • Selvaduray K.R., Radhakrishnan A.K., Kutty M.K., and Nesaretnam K. Palm Tocotrienols Inhibit Proliferation of Murine Mammary Cancer Cells and Induce Expression of IL-24 mRNA. J. of Interferon and Cytokine Research, 2010; 30(12): 909-916. [IF: 2.576]
  • Ling L.T., Radhakrishnan A.K., Subramaniam T., Cheng H.M. and Palanisamy U.D. Assessment of Antioxidant Capacity and Cytotoxicity of Selected Malaysian Plants. Molecules 2010; 15(4): 2139-2151. [IF: 1.988]
  • Chu W.L., Lim Y.W., Radhakrishnan A. K., and Lim P.E. Protective effect of aqueous extract from Spirulina platensis against cell death induced by free radicals. BMC Complementary and Alternative Medicine, 2010; 10(1): 53 PubMed cited
  • Er H.M., Lee H.L., Radhakrishnan A.K. The antiproliferative and antioxidant properties of leaf extracts of Pereskia bleo (Kunth) DC (Cactaceae) and their ability to limit natural and oxidant-induced apoptotic cell death. Journal of Science and Technology in the Tropics, 2010; 6: 31-38. Scopus cited
  • Shalini S. Kumar, Radhakrishnan A.K., Cheong, S.K. Immune responses in the microenvironment of a metastatic 4T1 mouse model. Egyptian Academic Journal of Biological Sciences, 2010; 2(2): 19-26.
  • Loganathan R., Selvaduray K.R., Radhakrishnan A. and Nesaretnam K.. Palm Oil: Rich in Health Promoting Phytonutrients. Palm Oil Developments, 2010; 50: 16-25
  • Loganathan R., Selvaduray K.R., Nesaretnam K. and Radhakrishnan A.K. The Health Promoting Effects of Phytonutrients found in Palm Oil. Malaysian J of Nutrition, 2010; 16(2): 309-322. PubMed cited
  • Sree Kumar S., Radhakrishnan A.K. and Cheong S.K. Rapid metastasis of breast cancer cells from primary tumour to liver. Pakistan J of Biological Sciences, 2010; 13(7): 303-315. PubMed cited
  • Abdul Hafid S.R., Radhakrishnan A.K. and Nesaretnam K. Tocotrienols are Good Adjuvants for Developing Cancer Vaccines. BMC Cancer, 2010; 10(5): 1-10 [IF: 3.15]
  • Radhakrishnan A.K., Lee A.L., Wong P.K., Kaur J., Aung H. and Nesaretnam K. Comparable effects on immune modulation following daily supplementation with tocotrienol-rich fraction (TRF) or alpha-tocopherol in normal human volunteers. British J. of Nutr., 2010; 101(6): 810-815. [IF: 3.446]
  • Choo Z.W., Chakravarthi S., Wong S.F., Nagaraja H.S., Thanikachalam P.M., Mak J.W., Radhakrishnan A. and Tay A. A comparative histopathological study of systemic candidiasis in association with experimentally induced breast cancer. Oncology Letters, 2010; 1: 215-222. [IF: 0.108]
  • Chakravarthi S., Choo Z.W., Nagaraja H.S., Wong S.F., Mak J.W., Thanikachalam P.M., Radhakrishnan A. and Tay A. Immunosuppressive effect of disseminated breast carcinoma on severity of hepatic Candidiasis. Research Journal of Immunology, 2010; 3(1): 1-11.
  • Nesaretnam K., Mahalingam D., Radhakrishnan A.K., Premier R. Daily Supplementation of Palm Tocotrienol-Rich Fraction (TRF) Increases Interferon-gamma Production and Lymphocyte Proliferation in Mice Immunized with Ovalbumin. Eur J. of Lipid Science and Technology, 2010; 112(5): 517-613. [IF: 1.487]
  • Montazeri S., Nalliah S. and Radhakrishnan A.K. Association between polymorphisms in human tumor necrosis factor-alpha (-308) and -beta (252) genes and development of gestational diabetes mellitus. Diabetes Research and Clinical Practice, 2010; 88(2): 139-145. [IF: 2.134]
  • Montazeri S., Nalliah S. and Radhakrishnan A.K. Is There a Genetic Variation Association in the IL-10 and TNF-a promoter gene with Gestational Diabetes Mellitus? Hereditas, 2010; 147(2): 94-102. [IF: 0.788 ]

2011

  • Uma Devi Palanisamy, Muniswaran Sivanathan, Ammu Kutty Radhakrishnan, Nagaraja Haleagrahara, Thavamanithevi Subramaniam, Gan Seng Chiew. An Effective Ostrich Oil Bleaching Technique Using Peroxide Value as an Indicator. Molecules, 2011, 16, 5709-5719. [IF:1.988]
  • Dulanthi Tudave, Ammu Radhakrishnan, Srikumar Chakravarthi, Nagaraja Haleagrahara. Modulation of C-reactive protein and tumour necrosis factor-alpha in collagen-induced arthritis in Dark Agouti rats: impact of collagen concentration on severity of arthritis. Inflamm Res., 2011, 60(10):897-907. [IF:2.004]
  • Nagaraja Haleagrahara, Srikumar Chakravarthi, Anupama Bangra Kulur and Ammu Radhakrishnan. Effects of chronic lead acetate exposure on bone marrow lipid peroxidation and antioxidant enzyme activities in rats. African Journal of Pharmacy and Pharmacology, 2011, 5(7):923-929. [IF: 0.5]
  • Chakravarthi S., Nagaraja H.S., Choo Zhen Wei, Wong S.F., Mak J.W. Ammu Radhakrishnan. A histopathologial study of cardiac Candidiasis and its behaviour under immunosuppressive effect for disseminated breast carcinoma. The Cardiology, 2011; 6(1): 1-7.
  • Uma Palanisamy, Thamilvaani Manaharan, Ling Lai Teng, Ammu K.C. Radhakrishnan, Thavamanithevi Subramaniam, Theanmalar Masilamani. Rambutan rind in the management of hyperglycemia. Food Research International, 2011; 44: 2278-2282. [IF: 2.416]
  • Gomez E.L., Gun S.C., Somnath S. D., D’Souza B., Lim A.L., Chinna K. and Radhakrishnan A.K. The prevalence of rheumatoid factor isotypes and anti-cyclic citrullinated peptides in Malaysian rheumatoid arthritis patients. Int J Rheum Dis., 2011, 14(1):12-17. [IF: 0.205]
  • Ramdas P., Rajihuzzaman M., Veerasenan S.D., Selvaduray K.R., Nesaretnam K. and Radhakrishnan A. K. Tocotrienol-treated MCF-7 Human Breast Cancer Cells Showed Downregulation of API5 and Upregulation of MIG6 Genes. Cancer Genomics Proteomics, 2011; 8(1):19-31. PubMed cited
  • Appukutty M., Radhakrishnan A.K., Ramasamy K., Abu Bakar A.M., Mohd Noor Ismail, Nik Shanita Safii, Chinna K., Poh B.K. Modulation of interferon gamma response through orally administered bovine colostrum in active adolescent boys. Biomedical Research, 2011; 22 (1): 18-22. PubMed cited
  • Mahalingam D., Radhakrishnan A.K., Amom Z., Ibrahim N. and Nesaretnam K. Effects of Supplementation with Tocotrienol-Rich Fraction on Immune Response to Tetanus Toxoid Immunisation in Normal Healthy Volunteers. Eur J Clin Nutr., 2011, 65(1):63-69.

2012

  • Radhakrishnan A.K., Sim, G.C., Cheong S.K. Comparing the ability of freshly generated and cryopreserved dendritic cell vaccine to inhibit growth of breast cancer in a mouse model. BioResearch Open Access, 2012; 1(5): 239-246. PubMed cited
  • Shonia Subramaniam, Srikumar Chakravarthi, Uma Devi Palanisamy, Nagaraja Haleagrahara and Ammu Radhakrishnan. Acute and subchronic oral toxicity assessment of the ethanolic extract from the rind of Nephelium lappaceum in rats. (Journal of Pharmacology and Toxicology, 2012; ISSN 1816-496X/ DOI: 10.3923/jpt.2012: 1-8 Scopus cited
  • Appukutty M., Radhakrishnan A.K., Ramasamy K., Ramasamy R., Abdul Majeed A.B., Ismail M.N., Safii N.K., Poh B.K., Chinna K., Haleagrahara N.. Colostrum supplementation protects against exercise - induced oxidative stress in the skeletal muscle in mice. BMC Research Notes, 2012; 5(1):649 PubMed cited
  • Shashi Kumar, Srikumar Chakravarthi, Gan Seng Chiew, Umadevi Palanisamy, Thavamanithevi Subramaniam, Ammu K. Radhakrishnan, Nagaraja, H. Standardised Nephelium lappaceum rind ethanolic extract has protective effect against collagen-induced arthritis. Journal of Biological Sciences, 2012; ISSN 1727-3048/ Scopus cited
  • Radhakrishnan, A.K., Nagarajah Lee and Young, M. L. The influence of admission qualification on the academic performance in the first and second year medical school performance: a study from the International Medical University (IMU). International e-Journal of Science, Medicine and Education, 2012; 6(2): 10-17.
  • Rebecca S.Y. Wong, Ammu K. Radhakrishnan. Tocotrienol Research: Past into Present. Nutrition Reviews, 2012; 70(9):483-490 (Epub 2012 Aug 17) [IF: 4.077] Review
  • Radhakrishnan, A. K. Advances in immunotherapy using dendritic cells. International e-Journal of Science, Medicine and Education, 2012; 6 (Suppl 1): S113-S117. Review
  • Rebecca S.Y. Wong, Ammu K. Radhakrishnan, Tengku Azmi Tengku Ibrahim, Soon-Keng Cheong. Delta- and gamma-tocotrienols induce classical ultrastructural apoptotic changes in human T lymphoblastic leukaemic cells. Microscopy and Microanalysis, 2012, 18(3):462-469. [IF: 3.259]
  • Selvaduray K.R., Radhakrishnan A.K., Kutty M.K., Nesaretnam K. Palm tocotrienols decrease levels of pro-angiogenic markers in human umbilical vein endothelial cells (HUVEC) and murine mammary cancer cells. Genes and Nutrition, 2012, 7(1):53-61. [IF: 3.015]

2013

  • Shantakumari Rajan, Nagaraja Haleagrahara, Karuthan Chinna, Abu Bakar Abdul Majeed, Radhakrishnan A.K. Bisphenol-A exposure during puberty interrupts non-social behaviour in young adult mice. Journal of Science and Technology in the Tropics, 2013; 9:91-102. Scopus cited
  • Abdul Hafid S.R., Srikumar Chakravarthi, Nesaretnam K. Radhakrishnan A.K. Tocotrienol-adjuvanted Dendritic Cells Inhibit Tumor Growth and Metastasis: A Murine Model of Breast Cancer. Plos One Journal, 2013; PLoS ONE 8(9): e74753. [IF: 4.511].
  • Loganathan R., Selvaduray K.S., Nesaretnam K., Radhakrishnan A.K. Differential and Antagonistic Effects of Palm Tocotrienols and Other Phytonutrients (Carotenoids, Squalene, Coenzyme Q10) on Breast Cancer Cells in vitro. Journal of Oil Palm Research, 2013; 25 (2): 208-215. [IF: 0.5]
  • Chu Wan Loy, Van Quynh, Radhakrishnan A. K. Effect of Spirulina (Arthrospira) Supplementation on the Immune Response to Tetanus Toxoid Vaccination in a Mouse Model. Journal of Dietary Supplements, 2013; 10(3):229-40. [IF: 0.35]
  • Gomez E.L., Gun S.C., Radhakrishnan A.K., Somanath S.D., Lim A.L., D’Souza B., Chinna, K. Ethnic differences in the prognostic utility of rheumatoid factor isotypes and anti-cyclic citrullinated peptides in rheumatoid arthritis patients. Modern Rheumatology, 2013; 23(4):716-721. [IF: 1.577]
  • Radhakrishnan A.K., Mahalingam D., Nesaretnam K., Selvaduray K.R., Supplementation with natural forms of vitamin E augments antigen-specific TH1-type immune response to tetanus toxoid. BioMed Research International, 2013; Volume 2013 Article ID 782067, 1-8. [IF: 2.880]
  • Radhakrishnan A.K., Raj V.L., Tan L.K., Liam C.K. Single nucleotide polymorphisms in the promoter of the human interleukin-13 gene is associated with asthma in Malaysian adults. BioMed Research International, 2013; Volume 2013 Article ID: 981012 1-7. [IF: 2.880]
  • Magalingam, K. B., Radhakrishnan, A., Haleagrahara, N. Rutin, a bioflavonoid antioxidant protects rat pheochromocytoma (PC-12) cells against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity. International journal of Molecular Medicine, 2013; 32(1), 235 [IF: 1.573]
  • Loganathan R., Selvaduray K.R., Nesaretnam K. Radhakrishnan A.K., Tocotrienols promote apoptosis in human breast cancer cells by inducing PARP cleavage and inhibiting NF-kappa B. Cell Proliferation, 2013; 46(2): 203-213 [IF: 2.521]
  • Nagaraja Haleagrahara, Dulanthi Tudawe, Srikumar Chakravarthi and Radhakrishnan A.K. Amelioration of collagen- induced arthritis in female Dark Agouti rats by glucosamine treatment. ISRN Pharmacology, 2013; 2013: Article ID: 562905: 1-7.
  • Ivan Kok Seng Yap, Ammu Kutty Radhakrishnan, Chee Onn Leong. Current concepts in cancer research. International e-Journal of Science, Medicine and Education, 2013; 7 (Suppl 1): S19-S31. Review

2014

  • George A, Chinnappan S, Chintamaneni M, Kotak C V, Choudhary Y, Kueper T, Radhakrishnan A.K. Anti-inflammatory effects of Polygonum minus (Huds) extract (LineminusTM) in in-vitro enzyme assays and carrageenan induced paw edema. BMC Complement Altern Med., 2014; 25; 14(1):355. [IF: 1.88]
  • Thamilvaani Manaharan, Srikumar Chakravarthi, Radhakrishnan A.K., and Uma Devi Palanisamy. In vivo toxicity evaluation of a standardized extract of Syzygium aqueum leaf. Toxicology Reports, 2014; 1; 718-725.
  • Kasthuri Bai Magalingam, Radhakrishnan A., Nagaraja Haleagrahara, Premdass Ramdas. Quercetin Glycosides Induced Neuroprotection by Changes in Gene Expression in a Cellular Model of Parkinson’s Disease. Journal of Molecular Neuroscience, 2014 [IF: 2.89]
  • Nagaraja Haleagrahara, Mirashini Swaminathan, Srikumar Chakravarthi and Ammu K. Radhakrishnan. Therapeutic Efficacy of Vitamin E d-tocotrienol in Collagen-Induced Rat Model of Arthritis. BioMed Research International, 2014; Volume 2014 Article ID: 539540 1-8. [IF: 2.880]
  • Kasthuri Bai Magalingam, Ammu Radhakrishnan, Nagaraja Haleagrahara, Protective effects of flavonol isoquercitrin, against 6-hydroxy dopamine (6-OHDA) - induced toxicity in PC12 cells. BMC Research Notes, 2014; 7:49. Pub-Med Cited
  • Ammu Radhakrishnan, Dulanthi Tudawe, Srikumar Chakravarthi, Gan Seng Chiew, Nagaraja Haleagrahara. Effect of ?tocotrienol in counteracting oxidative stress and joint damage in collageninduced arthritis in rats. Experimental and Therapeutic Medicine, 2014; 7 1408-1414 [IF: 0.344]
  • Shanmugam Somasundaram. Srikumar Chakravarthi, Ammu Radhakrishnan, Premdass Ramdas, Nagaraja Haleagrahara, Mangala Kumari. Therapeutic effect of curcumin supplementation in the modulation of NF-kB responsive genes in a collagen-induced arthritis rat model. British Journal of Medicine and Medical Research, 2014; 4(15): 2940-2954

2015

  • Loganathan R., Radhakrishnan A.K., Selvaduray K.R., Nesaretnam K. Selective anti-cancer effects of palm phytonutrients on human breast cancer cells. RSC Advances, 2015, 5, 1745-1753 [IF: 3.708]
  • Mahenderan Appukutty, Kalavathy Ramasamy, Shantakumari Rajan, Shalini Vellasamy, Rajesh Ramasamy and Ammu Kutty Radhakrishnan. Effect of Orally Administered Soy Milk fermented with Lactobacillus plantarum LAB12 and Physical Exercise on Murine Immune Responses. Beneficial Microbes, 2015 (accepted, in press) [IF: 1.5]
  • Afshan Sumera, Ammu Radhakrishnan, Abdul Aziz Baba, Elizabeth George. Beta-thalassemia and molecular chaperones. Blood Cells, Molecules and Diseases, 2015 (accepted, in press) [IF: 2.331]
  • Magalingam Kasthuri Bai, Ammu K. Radhakrishnan and Nagaraja Haleagrahara. Protective Mechanisms of Flavonoids in Parkinson’s Disease. Oxidative Medicine and Cellular Longevity, 2015 (accepted, in press) [IF:3.363]

 

Last updated on 12 February 2015

 

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