NG CHEW HEE

Designation/Title : Associate Professor Contact Information : Department of Pharmaceutical Chemistry
Tel: 03-2731 7483 ext 273
Fax: 03-8656 7229
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Education and Training

PhD Universiti Sains Malaysia
1995
MSc
Universiti Sains Malaysia 1991
BSc Universiti Sains Malaysia
1984

 

Research interests:

  • Biological Chemistry: artificial nucleases; DNA binding agents and gene transcription/protein binding modulation/inhibition; mitochondria and ROS
  • Medicinal Chemistry: Drugs and ROS; proteasome inhibitors; transport proteins and drug biodistribution
  • Anticancer Metallodrugs – rasional design; factors affecting efficacy and safety; mechanism of action

 

Research projects/grants:

  • Aldol Condensation of [M(I)(aa)Cl]: synthesis, characterization and biomedical properties (M = metal(II); I = intercalating or insertor ligand; aa = L- and D-amino acid; Cl- = anion), Fundamental Research Grant (FRGS), Ministry of Higher Education (MOHE), May 2012- Jun2014 – Co-researcher (originally Principal Researcher)
  • Metal Binding Study of Rice Metallothionein, FRGS, May2012-Jun2014 – Co-researcher
  • Anticancer property and mode of action of metal complexes of intercalating ligand and amino acids, MAKNA grant (2008-09): Main supervisor of MSc student who obtained this grant
  • Nucleolytic and anticancer properties of insulin-mimetic vanadium, zinc and cobalt complexes, eScience grant, MOSTI, Nov 2007-January 2010 - Principal Researcher
  • Basic mechanism and effect of binding transition metal complexes of amino acids and their derivatives to nucleic acids, SAGA grant, Akademi Sains Malaysia (ASM), 2005-2007 – Principal Research

 

 

Supervision of Postgraduates (MSc/PhD)
(Last 5 years – 2008-2012)

  • Wang Wai San – M.Sc. (2009 – Present) – Chief Supervisor
    Modification of chiral [Cu(phen)(aa)(H2O)]NO3 by Aldol condensation: synthesis, characterization and biological study
  • Chin Lee Fang – M.Sc. (2009 – Present) – Chief Supervisor
    Synthesis, characterization and biological properties of metal(II) polypyridyl complexes with OO-, ONO-, or NO- chelating coligands
  • Kong Siew Ming – M.Sc. (2008 – 2012) – Chief Supervisor
    Cytotoxicity, mode of action and selectivity of anticancer copper complexes
  • Von Sze Tin – M.Sc. (2007 – 2012) – Chief Supervisor
    Anticancer Property and Mode of Action of Metal(II) Complexes of Intercalating Ligand and Amino Acid
  • James Chong Kok Vei (2009 – 2012) – Chief Supervisor
    Study DNA interaction and nucleolytic property of optically active metal complexes
  • Tiong Yee Lian – M.Sc. (2007 – 2010) – Chief Supervisor
    Phenylenediamine induced oxidative stress and lipid peroxidation apoptosis of Mardin-Darby Canine Kidney cells
  • Tan Kong Wai – Ph.D. (2006 – 2009) – Joint Supervisor
    Synthesis, characterization and biological activities of transition metal complexes
  • Seng Hoi Ling – Ph.D (2006 – 2010) – Chief Supervisor
    Duplex and G-quadruplex DNA binding, nucleolytic property and topoisomerase I inhibition of different series of metal (II) complexes

 



Professional affiliations:

  • Malaysian Institute of Chemistry: Associate member (1999 - now)
  • Registered Chemist (1999 – now)
  • Malaysian Scientific Association: Member (2001 – now)
  • Society of Biological Inorganic Chemistry: Member (2011 – now)

 

Academic Awards:

  • ...

Recent publications
(last 5 years – 2008 -2012)

Journal

  • Ng C.H., Kong K.C., Von S.T., Balraj P., Jensen P., Thirthagiri E., Hamada H., Chikira M. (2008). Synthesis, characterization, DNA-binding study and anticancer property of ternary metal(II) complexes of EDDA and an intercalating ligand, Dalton Trans: 4  447-454.
  • Teoh S.G., Ng C.H., Lai T.F., Lim E.K., Mansor S.M., Balraj P., Chu T.L., B.M., Ng S.W., (2008).  Oxovanadium(IV) Dipicolinate: Structure, Nucleolytic and Anticancer Property, Modern Applied Science, 2: 117.
  • “3,4-dihyroxybenzaldehyde 4-phenylthiosemicarbazone”, Kong Wai Tan, Yang Farina, Chew Hee Ng, Mohd Jamil Maah, Seik Weng Ng, Acta Cryst E, 64, o1035 (2008).
  • “3,4-Dihydroxybenzaldehyde thiosemicarbazone”, Kong Wai Tan, Yang Farina, Chew Hee Ng, Mohd Jamil Maah and Seik Weng Ng, Acta Cryst.E, 64, o1073 (2008).
  • “Factors affecting nucleolytic efficiency of some ternary metal complexes with DNA binding and recognition domains. Crystal and molecular structure of Zn(phen)(edda)’, Hoi-Ling Seng, Han Kiat Alan Ong, Raja Noor Zaliha Raja Abd. Rahman, Bohari M. Yamin, Edward R.T. Tiekink, Kong Wai Tan, Mohd Jamil Maah, Ignez Caracelli, Chew Hee Ng, J. Inorg. Biochem., 102 (2008) 1997.
  • “2,5-Dihydroxybenzaldehyde 4-methylthiosemicarbazone”, Kong Wai Tan, Chew Hee Ng, Mohd Jamil Maah, Seik Weng Ng, Acta Cryst E, E64 (2008) o1344.
  • “2,4-Dihydroxybenzaldehyde 4-ethylthiosemicarbazone”, Kong Wai Tan, Chew Hee Ng, Mohd Jamil, Seik Weng Ng, Acta Cryst E64 (2008) o2123
  • “Chlorido(2-methyl-4-oxo-4H-pyran-3-olato-κ2O3,O4)(1,10-phenanthroline- κ2N,N’)copper(II)”, Kong Wai Tan, Chew Hee Ng, Mohd Jamil Maah, Seik Weng Ng, Acta Cryst.E64 (2008) m1104.
  • “2,4-Dihydroxybenzaldehyde 4-methylthiosemicarbazone”, K. W. Tan, C. H. Ng, M. J. Maah, S. W. Ng, Acta Cryst. E64 (2008) o2224.
  • “(4-Hydroxy-2-oxidobenzaldehyde thiosemicarbazonato- 3O2,N1,S)(1,10-phenanthroline- 2N,N')zinc(II) dimethyl sulfoxide disolvate monohydrate, K. W. Tan, C. H. Ng, M. J. Maah, S. W. Ng, Acta Cryst. E65 (2009) m61.
  • “ -Nitrilotriacetato-tris(1,10-phenanthroline)dizinc(II) nitrate hexahydrate”, L. F. Chin, Chew Hee Ng, S. W. Ng, Acta Cryst. (2009). E65, m40 (published online 10 Dec 2008)
  • “Aqua(iminodiacetato- 3O,N,O')(1,10-phenanthroline- 2N,N')cobalt(II) monohydrate”, H. L. Ng, C. H. Ng and S. W. Ng, Acta Cryst. (2009). E65, m41  (Online 10 December 2008).
  • “Aqua(iminodiacetato- 3O,N,O')(1,10-phenanthroline- 2N,N')zinc(II) sesquihydrate,” H. L. Ng, C. H. Ng, S. W. Ng, Acta Cryst. E65 (2009) m89.
  • “Characterization, nucleolytic, cytotoxic and antibacterial property of tetrakis(μ-4-chloro-2-nitrobenzoato-κ2O,O′)bis[aquacopper(II)], tetrakis(μ-2-chloro-6-fluorobenzoato-κ2O,O′)bis[aquacopper(II)] and tetrakis(μ-2-chlorobenzoato-κ2O,O′)bis[aquacopper(II)]”, Eng-Khoon Lim, Siang-Guan Teoh, Siu-Mun Goh, Cynn-Dee Ch’ng, Chew-Hee Ng, Hoong-Kun Fun, Mohd Mustaqim Rosli, Nazalan Najimudin, Hooi-Kheng Beh, Lay-Jing Seow, Norhayati Ismail, Zhari Ismail, Mohd Zaini Asmawi, Yew-Hoong Cheah, Polyhedron 28 (2009) 1320.
  • “Copper(II) complexes of methylated glycine derivatives: effect of methyl substituent on their DNA binding and nucleolytic property”, Hoi Ling Seng, Kong Wai Tan, Mohd Jamil Maah, Wee Tee Tan, Hirokazu Hamada, Makoto Chikira, Chew Hee Ng, Polyhedron 28 (2009) 2219
  • “(4-Hydroxy-2-oxidobenzaldehyde 4-ethylthiosemicarbazone-κ4O2,N1,S,O2) bis[chloridozinc(II)] dimethylsulfoxide trisolvate, Kong Wai Tan, Chew Hee Ng, Mohd Jamil Maah, Seik Weng Ng, Acta Cryst. Section E (2009), E65, m549.
  • “[1-(4-Hydroxy-2-oxidobenzylidene)-4-phenylthiosemicarbazonato- 3N,O,S](1,10-phenanthroline- 2N,N')zinc(II)-4,4'-bipyridine (2/1)”, K.W. Tan, Mohd Jamil Maah, C. H. Ng, S. W. Ng,  Acta Cryst. (2009). E65, m920
  • “Chlorido(pentane-2,4-dionato- 2O,O')(1,10-phenanthroline- 2N,N')copper(II)”, Y.S. Wong, C. H. Ng, S. W. Ng,  Acta Cryst. (2009). E65, m934
  • “Crystal structure, DNA binding studies, nucleolytic property and topoisomerase I inhibition of zinc complex with 1,10-phenanthroline and 3-methyl-picolinic acid”, Hoi-Ling Seng, Sze-Tin Von, Kong-Wai Tan, Mohd Jamil Maah, Seik-Weng Ng, Raja Noor Zaliha Raja Abd Rahman, Ignez Caracelli, Chew-Hee Ng, BioMetals, 23 (2009) 99-118.
  • Kong Wai Tan, Mohd Jamil Maah, Chew Hee Ng, Seik Weng Ng, Bis([mu]-5-hydroxy-2-{[2-(N-phenylthiocarbamoyl)hydrazin-1-ylidene]methyl}phenolato)- bis[chloridozinc(II)] N,N-dimethylformamide tetrasolvate, Acta Cryst.E: 66 (5), 2010,  m569.
  • Shao Liang Lim, Chew Hee Ng, Siang Guan Teoh, Wan-Sin Loh and Hoong-Kun Fun "Diaqua(1,4,8,11-tetraazacyclotetradecane)nickel(II) fumarate tetrahydrate”, Acta Cryst. E66, 2010, m737-m738.
  • Hoi-Ling Seng, Sze-Tin Von, Kong-Wai Tan, Mohd Jamil Maah, Seik-Weng Ng, Raja Noor Zaliha Raja Abd Rahman, Ignez Caracelli, Chew-Hee Ng, “Crystal structure, DNA binding studies, nucleolytic property and topoisomerase I inhibition of zinc complex with 1,10-phenanthroline and 3-methyl-picolinic acid”, BioMetals, 2010, 23, 99.
  • Lee Fang Chin, Siew Ming Kong, Hoi Ling Seng, Kong Soo Khoo, Rajamurthy Vikneswaran, Siang Guan Teoh, Munirah Ahmad, Soo Beng Alan Khoo, Mohd  Jamil Maah, Chew Hee Ng, “Synthesis, characterization and biological properties of cobalt(II) complexes of 1,10-phenanthroline and maltol”, J. Inorg. Biochem., 2011, 105, 339.  (Mac 2011)
  • Sze-Tin Von, Hoi Ling Seng, Hong-Boon Lee, Seik Weng Ng, Makoto Chikira, Yasuke Kitamura, Chew-Hee Ng, “DNA molecular recognition and cellular selectivity of anticancer metal(II) complexes of EDDA and phenanthroline: multiple targets”, J. Biol. Inorg. Chem., 2012, 17, 57.
  • Kong Wai Tan, Hoi Ling Seng, Fei Shen Lim, Shiau-Chuen Cheah, Chew Hee Ng, Kong Soo Koo, Mohd Rais Mustafa, Seik Weng Ng, Mohd Jamil Maah, “Towards a selective cytotoxic agent for prostate cancer: Interaction of zinc complexes of polyhydroxybenzaldehyde thiosemicarbazones with Topoisomerase I”, Polyhedron, 2012, 38, 275. (May 2012)
  • Chew-Hee Ng, et al, “[Zn(phen)(O,N,O)(H2O)] and [Zn(phen)(O,N)(H2O)] with O,N,O = 2,6-dipicolinate and N,O = L-threoninate: synthesis, characterization, biomedical properties”, J. Biol. Inorg. Chem., 2012 (Aug), in press.
  • Hoi-Ling Seng, Wai-San Wang, Siew-Ming Kong, Han-Kiat Alan Ong, Yip-Foo Win, Raja Noor Zaliha Raja Abd Rahman, Makoto Chikira, Weng-Kee Leong, Munirah Ahmad, Soo-Beng Alan Khoo, Chew-Hee Ng, “Biological and cytoselective anticancer properties of copper(II)-polypyridyl complexes modulated by auxillary methylated glycine ligand”, Biometals, 2012 (Aug), in press
  • Quah, J.X., Ambu, S., Lim Y.A. L., M.A.K. Mahdy and Mak.J.W. (2011).   Molecular Identification   of Cryptosporidium parvum from avian hosts.  Parasitology: 138 (5) 573-577.

 

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