EBENEZER CHITRA

Designation/Title : Lecturer / Dr
Department: Division of Human Biology, School of Medicine, IMU
Tel: 03-27317519
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Education and Training

M.Sc. (Biotechnology) TNAU, India 1997
Ph.D. (Immunology) JNU, India 2005

 

Research interests:

  • Cancer Biology
  • Cell and Molecular Biology
  • Microbiology & Immunology

 

Research projects/grants:


External Research Grant:

2014

  • Effect of madecassoside in reducing oxidative stress and blood glucose and in protecting the β-cells in streptozotocin-nicotinamide induced diabetes in rats. FRGS RM 135000 Co-PI
  • Post-translational regulation of glutamine metabolism by acetylases and deacetylases in cancer cells under hypoxic conditions. FRGS RM 151650 Co-PI
  • Evaluation of the mechanism of action of lactoferricin B peptide in the inhibition of breast cancer. FRGS RM 165440 – PI

2013

4. Development of Novel Chitosan-flavonoids (Propolis Ethanolic Extract) Nanoformulations Against Enterococcus Faecalis in the Root Canal Using Extracted Human Tooth Model. ERGS RM 221000 Co-PI

 

Internal projects:

2014

  • Elucidation of the molecular mechanisms of the cardioprotective effect of ellagic acid in rat cardiomyocyte cell line. IMU RM 20000 - PI

2013

  • The role of hypoxia inducible factor -1alpha (HIF-1α) in the regulation of glutamine metabolism in cancer cells IMU RM 20000 Co-PI
  • Pharmacodynamics of ellagic acid on cardiac fibrosis in experimentally induced myocardial infarction IMU RM 20000 Co-PI
  • Effect of HDGF (Hepatoma derived growth factor)-derived peptides on cell growth and apoptosis of cancer cell lines IMU RM 20000 Co-PI
  • Effect of bovine lactoferricin in the modulation of metalloproteases and tissue inhibitor of metalloproteases levels in metastatic and non-metastatic cell lines IMU RM20000 PI

2012

  • Role of Malaysian snake venom component in disrupting the extra cellular matrix proteins and its effect on cancer cell invasions IMU RM 20000 Co-PI
  • Study of the role of members of Ras/Akt pathways on the transformation ability of retroviral oncogene Env IMU RM 20000 PI
  • Gene profiling of Malaysian cobra venom metalloproteases (MCVMP) treated 3T3 cells IMU RM 20000 Co-PI

2011

  • Oncogene induced changes in Migratory and proliferative properties of cells and alterations in intracellular signalling pathways IMU RM 20000 PI
  • Identification of wound healing inhibitory components from snake venom IMU RM 20000 Co-PI

 

Supervision of Postgraduates (MSc/PhD)

  • Ong Teik Hwa Development of novel chitosan nanoformulations against biofilm formed by E. faecalis M.Sc. IMU 2014-16

Professional affiliations:

  • Indian Immunology Association Member

 

Academic Awards:

  • National Institute of Immunology Fellowship – Ph.D. (1999-2004)
  • ICAR Junior Research Fellowship - M.Sc. (1995-1997)
  • National Eligibility Test (NET) for lectureship (1999)
  • The Governor’s prize for the best B.Sc. (Ag) student of TNAU (1994)
  • The Chancellor’s prize for the best B.Sc. (Ag) student of TNAU (1994)
  • Dr. T.S.S. Rajan prize for the best B.Sc. (Ag) student of TNAU (1994)
  • MASU prize for the best B.Sc. (Ag) student of AC&RI, Madurai (1994)
  • Madurai Masonic Trust Merit Scholarship (1990-94)
  • The John Plough Works medal (1991-1992)
  • The Pioneer’s medal (1990-1991)

 

 

Recent publications

  • Yueh-Liang Tsou, Yi-Wen Lin, Hsuen-Wen Chang, Hsiang-Yin Lin, Hsiao-Yun Shao, Shu-Ling Yu, Chia-Chyi Liu, Ebenezer Chitra, Charles Sia, Yen-Hung Chow. Heat Shock protein 90: Role in Enterovirus 71 Entry and Assembly and Potential Target for Therapy. PLoS One 2013; 8(10):e77133. IF: 4.4
  • Yi-Wen Lin, Shu-Ling Yu, Hsiao-Yun Shao, Hsiang-Yin Lin, Chia-Chyi Liu, Kuang-Nan Hsiao, Ebenezer Chitra, Tsou YL, Chang HW, Charles Sia, Pele Chong, Yen-Hung Chow. Human SCARB2 Transgenic Mice as an Infectious Animal Model for Enterovirus 71. PLoS One 2013, 8(2):e57591. IF: 4.4
  • Yi-Wen Lin, Hsiang-Yin Lin, Yueh-Liang Tsou, Ebenezer Chitra, Kuang-Nan Hsiao, Hsiao-Yun Shao, Chia-Chyi Liu, Charles Sia, Pele Chong, Yen-Hung Chow. Human SCARB2-mediated entry and endocytosis of EV71. PLoS One, 2012, 7(1):e30507. IF: 4.4
  • Rupali Gund, Ebenezer Chitra, Krishnamurthy Thyagarajan, Ashutosh Chaudhry, Anna George, Vineeta Bal, and Satyajit Rath. Antigenic ligand density modulates execution of naïve CD8+ T cell response programme. J Immunol. 2012, 188, 110.1 IF: 5.788
  • Hsiao-Yun Shao, Yi-Wen Lin, Shu-Ling Yu, Hsiang-Yin Lin, Ebenezer Chitra, Yung-Chen Chang, Charles Sia, Pele Chong, Ming-Tao Hsu, Olivia L Wei, Yen-Hung Chow. Immunoprotectivity of HLA-A2 CTL peptides derived from respiratory syncytial virus fusion protein in HLA-A2 transgenic mouse. PLoS One, 2011, 6(9): e25500. IF: 4.4
  • Ebenezer Chitra, Yi-Wen Lin, Fabian Davamani, Kuang-Nan Hsiao, Charles Sia, Shih-Yang Hsieh, Olivia L Wei, Jen-Hao Chen and Yen-Hung Chow. Functional interaction between Env oncogene from Jaagsiekte sheep retrovirus and tumor suppressor Sprouty2. Retrovirology 2010, 7: 62. IF: 6.47 Citations: 2

 

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