RAMKUMAR RAJENDRAN

Designation/Title: Lecturer
Department: Life Sciences, School of Pharmacy
Tel: 03-2731 7567
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Education and Training

Post Doc University of Manchester, UK 2012
PhD University of Manchester, UK 2011
BPharm The Tamilnadu Dr MGR Medical University, India 1998

 

Research interests:

  • Cancer Metabolism
  • Post Translational Modifications
  • P53, HIF-1α, SIRT1 and PCAF
  • Hypoxia and DNA Damage

 

Research projects/grants:

  • Post-translational regulation of glutamine metabolism by acetylases and deacetylases in cancer cells under hypoxic conditions - Fundamental Research Grant Scheme (FRGS) by the Ministry of Higher Education, Malaysia – RM 151,650 (2014)

 

Supervision of Postgraduates (MSc/PhD)
(Last 5 years – 2010 - 2014)

  • Investigation of the effects of glucose/glutamine restriction on lactate dehydrogenase and glutaminase in cancer cells under hypoxic conditions – Amy Chong, MSc in Molecular Medicine, 2014-2015

Professional affiliations:

  • Biochemical Society, UK
  • British Association for Cancer Research (BACR, UK)
  • European Association for Cancer Research (EACR)
  • Tamilnadu Pharmacy Council, India

 

Academic Awards:

  • Overseas Research Studentship, University of Manchester, 2008-2010

 

Recent publications
(last 5 years – 2010 - 2014)

Journal

  • Travis Leung, Ramkumar Rajendran, Subir Singh, Richa Garva, Marija Krstic-Demonacos and Constantinos Demonacos (2013) Cytochrome P450 E1 (CYP2E1) regulates the response to oxidative stress and migration of breast cancer cells. Breast Cancer Research, 15(6)R107.
  • Tian, K., Rajendran, R., Doddananjaiah, M., Krstic-Demonacos, M., & Schwartz, J. M. (2013). Dynamics of DNA Damage Induced Pathways to Cancer. PloS one, 8(9), e72303.
  • Rajendran, R., Garva, R., Ashour, H., Leung, T., Stratford, I., Krstic-Demonacos, M., & Demonacos, C. (2013). Acetylation mediated by the p300/CBP-associated factor determines cellular energy metabolic pathways in cancer. International journal of oncology, 42(6), 1961.
  • Andreou, K., Rajendran, R., Krstic-Demonacos, M., & Demonacos, C. (2012). Regulation of CXCR4 gene expression in breast cancer cells under diverse stress conditions. International journal of oncology, 41(6), 2253.
  • Kadirvel, M., Salem Abudalal, A., Rajendran, R., Gbaj, A., Demonacos, C., & Freeman, S. (2012). myo-Inositol esters of indomethacin as COX-2 inhibitors. Carbohydrate Research, 355, 13-18.
  • Rajendran, R., Garva, R., Krstic-Demonacos, M., & Demonacos, C. (2011). Sirtuins: molecular traffic lights in the crossroad of oxidative stress, chromatin remodeling, and transcription. BioMed Research International, 2011.
  • Kadirvel, M., Rattray, N. J., Rajendran, R., Zalloum, W. A., Gbaj, A., Demonacos, C., & Freeman, S. (2011). Bioreductive molecular probe: fluorescence signalling upon reduction of an azo group. New Journal of Chemistry, 35(3), 701-708.
  • Arthanari, Y., Pluen, A., Rajendran, R., Aojula, H., & Demonacos, C. (2010). Delivery of therapeutic shRNA and siRNA by Tat fusion peptide targeting bcr–abl fusion gene in Chronic Myeloid Leukemia cells. Journal of Controlled Release, 145(3), 272-280.
  • Lynch, J. T., Rajendran, R., Xenaki, G., Berrou, I., Demonacos, C., & Krstic-Demonacos, M. (2010). The role of glucocorticoid receptor phosphorylation in Mcl-1 and NOXA gene expression. Molecular cancer, 9(1), 38.

 

 

 

 

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