Thiagarajan Madheswaran

Designation/Title : Lecturer
Department: Pharmaceutical Technology,School of Pharmacy
Tel: 03-27317075 / 010-2768019
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Education and Training

PhD in Pharmaceutical sciences Yeungnam University, South Korea 2010-2014
MPharm The Tamil Nadu Dr. MGR Medical University, India 2006-2008
BPharm The Tamil Nadu Dr. MGR Medical University, India 2001-2005

 

Research interests:

  • Topical delivery/transdermal delivery using nanoparticles
  • Self-assembled liquid crystalline nanoparticle-based drug delivery
  • Nanoparticle-based drug delivery for cancer therapy
  • Nanoparticle-loaded hydrogel

 

Research projects/grants:

Principal investigator

  • IMU BPharm project, International Medical University, Malaysia, Entrapment of berberine into liquid crystalline nanoparticles surface-modified with chitosan-folate conjugates for enhancing anticancer activity (May-2016 to Oct-2016)
  • IMU BPharm project, International Medical University, Malaysia, Formulation development of berberine-loaded lipid nanoparticles and in vitro evaluation of their antimicrobial activity (May-2015 to Oct-2015)
  • IMU self-study module Dental program project, International Medical University, Malaysia, Formulation development and in vitro evaluation of triamcinolone acetonide-loaded bioadhesive gels for the treatment of oral ulcers (June-2015 to Dec-2015)

 

Co-investigator

  • IMU BPharm project, International Medical University, Malaysia, Preparation and characterization of sustained release nanostructured lipid carrier systems of indomethacin to enhance skin penetration (May-2015 to Oct-2015)
  • IMU BPharm project, International Medical University, Malaysia, Development and Characterization of Photocrosslinked Implants for Controlled Ocular Drug Delivery (May-2015 to Oct-2015)
  • IMU BPharm project, International Medical University, Malaysia, Design of gastroretentive floating drug delivery systems by varying different gas-generating agents (May-2015 to Oct-2015)

 

Professional affiliations:

  • Registered pharmacist, Tamil Nadu State Pharmacy Council, India.
  • Member of Association of Pharmaceutical Teachers of India.
  • Controlled Release Society, Malaysian Chapter.

 

Academic Awards:

  • Best Poster Award in the 11th Asia-Pacific Congress on Dental and Oral Health Bangkok, Thailand (25-27th July 2016). Title: Formulation, development and in vitro evaluation of bio adhesive gels loaded with triamcinolone acetonide for the treatment of oral ulcers.
  • Brain Korea-21 fellowship for doctoral degree (Sep 2010-Aug 2012).
  • Best outgoing student in Master of Pharmacy (KMCH college of Pharmacy, Coimbatore).
  • Best GATE scorer award in Bachelor of Pharmacy (The Erode college of Pharmacy, Erode), Graduate Aptitude Test in Engineering (GATE 2005-Pharmaceutical sciences) conducted by (Indian Institute of Technology (IIT)-Bombay) with percentile score of 90.61, and received full scholarship for MPharm.

 

Recent publications
(last 5 years – 2010 -2014)

  • Madheswaran T, Baskaran R, Sundaramoorthy P, Yoo BK, Enhanced skin permeation of 5α-reductase inhibitors entrapped into surface-modified liquid crystalline nanoparticles. Archives of Pharmacal Research. 2015 April;38(4):534-542 (IF:2.49).
  • Baskaran R, Madheswaran T, Sundaramoorthy P, Kim HM, Yoo BK, Entrapment of curcumin into monoolein-based liquid crystalline nanoparticle dispersion for enhancement of stability and anticancer activity. International Journal of Nanomedicine. 2014 June;9(1):3119—3130 (IF:4.32).
  • Madheswaran T, Baskaran R, Yong CS, Yoo BK, Enhanced topical delivery of finasteride using glyceryl monooleate-based liquid crystalline nanoparticles stabilized by cremophor surfactants. AAPS PharmSciTech. 2014 Feb;15(1):44-51 (IF 1.95).
  • Madheswaran T, Baskaran R, Thapa RK, Rhyu JY, Choi HY, Kim JO, Yong CS, Yoo BK, Design and in vitro evaluation of finasteride-loaded liquid crystalline nanoparticles for topical delivery, AAPS PharmSciTech. 2013 Mar;14(1):45-52 (IF 1.95).
  • Thapa RK, Baskaran R, Madheswaran T, Kim JO, Yong CS, Yoo BK, Preparation, Characterization, and Release Study of Tacrolimus-Loaded Liquid Crystalline Nanoparticles, Journal of Dispersion Science and Technology. 2013;1(34):72-77 (IF 1.12).
  • Thapa RK, Baskaran R, Madheswaran T, Rhyu JY, Kim JO, Yong CS, Yoo BK, Effect of saturated fatty acids on tacrolimus-loaded liquid crystalline nanoparticles, Journal of drug delivery science and technology, 2013;23(2):137-141 (IF 0.7).
  • Thapa RK, Baskaran R, Madheswaran T, Kim JO, Yong CS, Yoo BK, In vitro release and skin permeation of tacrolimus from monoolein-based liquid crystalline nanoparticles, Journal of drug delivery science and technology, 2012;22(6):479-484 (IF 0.62).
  • Kumarappan C, Vijayakumar M, Thilagam E, Balamurugan M, Thiagarajan M, Senthil S, Das SC, Mandal SC, Protective and curative effects of polyphenolic extracts from Ichnocarpus frutescense leaves on experimental hepatotoxicity by carbon tretrachloride and tamoxifen. Annals of Hepatology. 2011 Jan-Mar;10(1):63-72 (IF 2.19).
  • Dharuman, JG, Rajasekaran A, Sivakumar KK, Thiagarajan M, Sivakumar K, Bioequivalence study and bioanalytical method development of levofloxacin tablets in albino rat plasma using RP-HPLC method. Archives of Applied Science Research, 2010;2(4):103-110.
  • Mohankandhasamy R, Dharuman J, Ponnilavarasan I, Thiagarajan M, High–performance liquid chromatography method for the quantification of pantoprazole in rat plasma, International Journal of Chemical and Technology research, 2010; 2:885-895.

 

Oral presentations

  • Madheswaran T, Baskaran R, Yoo BK. In vitro and in vivo evaluation of skin permeation and distribution of 5α-reductase inhibitors using chitosan-coated liquid crystalline nanoparticles, Pharmacy and Pharmaceutical Sciences Conference 2015, August 1-2, International Medical University, Kuala Lumpur, Malaysia.

 

Poster presentations

  • Madheswaran T, Brandon AJT, Le Jun, Lim TH, Kumar SG, Shadab Md, Formulation development and optimization of berberine-loaded lipid nanoparticles for topical delivery, Pharmacy and Pharmaceutical Sciences Conference 2015, August1-2, International Medical University, Kuala Lumpur, Malaysia.
  • Goo BL, Madheswaran T, Baskaran R, Kim YJ, Jo A, Yoo BK. Effect of laser treatment on skin permeation enhancement of finasteride and dutasteride using liquid crystalline nanoparticles as carrier. 2014, 8th World Congress for Hair Research. May 14-17. Jeju, S.Korea.
  • Madheswaran T, Baskaran R, Kim JO, Yong CS and Yoo BK. Liquid crystalline nanoparticles stabilized by polyoxyethylated surfactants to enhance the topical delivery of finasteride. 2013, Proceedings of the Spring International Convention of the Pharmaceutical Society of Korea. April 18-19. Jeollanam-do, S.Korea.
  • Madheswaran T, Baskaran R, Kim JO, Yong CS and Yoo BK. Investigation of penetration enhancement property of liquid crystalline nanoparticles in porcine skinusing attenuated total reflectance infrared spectroscopy. 2013 Proceedings of the Spring International Convention of the Pharmaceutical Society of Korea. April 18-19. Jeollanam-do, S.Korea.
  • Madheswaran T, Baskaran R, Thapa RK, Kim JO, Yong CS and Yoo BK. In vitro drug release and skin permeation study of finasteride-loaded monoolein nanoparticles for topical delivery. 2012 Proceedings of the International Congress of Korean Federation of Pharmaceutical Societies. April 18-21. Jeju, S.Korea
  • Madheswaran T, Baskaran R, Thapa RK, Kim JO, Yong CS and Yoo BK. Preparation, Characterization and In Vitro Release of Liquid Crystalline Nanoparticles Containing Finasteride, 2011, AAPS Annual Meeting and Exposition, Walter E. Washington Convention Center, Washington D.C.(USA), Oct. 23-27.
  • Baskaran R, Madheswaran T, Thapa RK, Yong CS and Yoo BK. Development of Finasteride Liquid Crystalline Nanoparticles for the Topical Application: Preparation, Characterization and In-vitro Release Study, Pharmaceutical Sciences for the Future of Medicines, Prague, Czech Republic, June 13-17(2011).

 

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