Dr. SREENIVASA RAO SAGINEEDU

Designation/Title : Lecturer
Department: Pharmaceutical Chemistry
Tel: 03-2731 7517; 012-9247923
Fax: 03-8656 7229
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Education and Training

PhD Universiti Putra Malaysia 2011
M.Pharm Andhra University 1998
B.Pharm Andhra University 1996

 

Research interests:

  • Drug design and synthesis
  • Drug Discovery and development
  • Organic spectroscopy
  • Pharmaceutical Analysis
  • Metabolomics

 

Research Projects/Grants:

  • ‘Drug-like ent-Labdane Diterpenoids as Neuroprotective Agents Targeting Amyloid-ß-Induced Neurotoxicity by Suppressing NF-kB and Reactive Oxygen Species: Semisynthesis and Biological Evaluation’ funded by eScienceFund (2013), Ministry of Science, Technology and Innovation, Malaysia; Principle-Researcher.
  • ‘Structure-based optimisation of the novel thiazolopyridines for the treatment of obesity’ funded by Exploratory Research Grant Scheme (2013), Ministry of Education, Malaysia; Co-Researcher.
  • 'Identification Of Chemical Pharmacophores For The Development Of New Generation Broad Spectrum Antibiotics Effective Against Multi-Drug Resistant Bacteria’ funded by Fundamental Research Grant Scheme (2013), Ministry of Education, Malaysia; Co-Researcher.
  • SRJ23 and its Derivatives as New Anticancer agents Targeting RAS-MAP Kinase and NF-kB Pathways: In Vitro, In Vivo, in Silico and Protein Crystallographic Approaches funded by RUGS (2012), UPM, Co-Researcher.

 

Supervision of Postgraduates (MSc/PhD)
(Last 5 years – 2009 - 2013)

  • ....

 

Professional affiliations:

  • Member, the European Association of Cancer Research (EACR)
  • Member, Pharmacy Council of India

 

Academic Awards:

  • University Grants Commission Fellowship, 1996, Andhra University India.
  • Graduate Research Fellowship, 2006, UPM, Malaysia

Recent publications
(last 5 years – 2009 - 2013)

Journal

  • Talei, D., Valdiani, A., Maziah, M., Sagineedu. S. R., Saad, M.S. (2013) Analysis of the Anticancer Phytochemicals in Andrographis paniculata Nees. under Salinity. Biomed Research International, http://dx.doi.org/10.1155/2013/319047.
  • Hocker, H. J., Cho, K. J., Chen, C. Y., Rambahal, N., Sagineedu, S. R., Shaari, K., Stanslas, J., Hancock, J. F., Gorfe, A. A. (2013) Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function. Proceedings of the National Academy of Sciences of the United States of America, 110: 10201-10206.
  • Jayakayatri, J., Niazlin, M. T., Mohd Nasir, M. D., Siti Norbaya, M., Rohani, M. Y., Farida, J., Sagineedu, S. R., Arunkumar, K. (2013) Prevalence of macrolide resistance and in vitro activities of six antimicrobial agents against clinical isolates of Streptococcus pneumoniae from a multi-center surveillance in Malaysia. The Medical journal of Malaysia, 68:119-24.
  • Lim, C. W., Chan, T. K., Ng, D. S. W., Sagineedu, S. R., Stanslas, J., Wong, W. S. F. (2012) Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer. Clinical and Experimental Pharmacology and Physiology: 39, 300-310.
  • Wong, H. C., Sagineedu, S. R., Lajis. N. H., Loke, S. C., Stanslas, J. (2011) Andrographolide induces cell cycle arrest and apoptosis in PC-3 prostate cancer cells. African Journal of Pharmacy and Pharmacology: 5, 225-233.

 

 

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