Lo Yoke Lin

Designation/Title : Associate Professor
Department: Pharmacy Practice
Tel: 03-2731 7490
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

 

 

 

 

 

Education and Training

PhD
University of Queensland, Australia 2011
MSc (Clinical)
Universiti Sains Malaysia, Malaysia 2002
Bachelor of Pharmacy Monash University, Australia 1979

 

Research interests:

  • Clinical Pharmacy
  • Clinical Pharmacology
  • Pharmacometrics

 

Research projects/grants:
National Research & Development Grants:

  • University of Malaya Research grant (UMRG). Pharmacokinetic-pharmacodynamic (PKPD) And Toxicokinetic Analyses of 1'S-1'-acetoxychavicol acetate (ACA) (PI). RM 85,000 (2015-2018)
  • University of Malaya Research grant (UMRG). Sub-chronic and chronic safety studies, in vitro and in vivo pharmacokinetic-pharmacodynamic analyses of the combination therapy of 1'S-1'-acetoxychavicol acetate (ACA) and recombinant human alpha fetoprotein (rhAFP) complex against rat xenograft prostate and lung cancer models. RM 1,565,000 (2015-2018)
  • Postgraduate Research Grant (PPP) University of Malaya. A predictive model of adiponectin levels in pediatric patients with obesity or diabetes or both obesity and diabetes (PI). RM 18,000 (2014-2017)
  • High Impact Research - Ministry of Education (HIR-MOE) Cycle 1 . The determination of the population pharmacokinetic-pharmacodynamic profile of levetiracetam using a modeling and simulation approach (PI). RM 203,309 (2011-2016)
  • University of Malaya Research grant (UMRG). Efficacy and safety of a colistin loading dose, population pharmacokinetic-pharmacodynamic profiles and bacterial clearance rate In critically ill patients with extensively drug-resistant Acinetobacter Baumanii (xdrab) infections. RM 118,140 (2013-2016)
  • Urusetia Jawatankuasa Pengurusan Penyelidikan (JPP-IMR). Population Pharmacokinetics-Pharmacodynamics (PKPD) of colistin in critically ill patients with multi-drug resistant Gram-negative bacterial infection: A Malaysian Scenario. RM248,400 (2013-2016)

 

Supervision of Postgraduates (Clinical Master/Master by research/PhD)
(Last 5 years – 2011-2016)

  • Prospective evaluation of vancomycin dosing in premature infants in Neonatal Intensive care Unit (NICU), University of Malaya Medical Centre (UMMC) - Nor Izwah Binti Mohamed Kamarudin, Clinical master of Pediatrics (completed Aug 2013).
  • Modeling and simulation approach towards quality use of antiepileptic drugs in adult Malaysian patients with epilepsy – Yeap Li Ling, PhD (completed March 2016).
  • Enhancement of quality use of novel oral anticoagulants (NOAC) and evaluation of a new bleeding risk stratification method of NOAC in patients with nonvalvular atrial fibrillation - Semira Abdi Beshir, PhD (2014 - ongoing).
  • Childhood obesity and its impact on the pharmacokinetics of metformin – Soh Yee Chang, PhD (2014 - ongoing)
  • In vitro drug metabolism and in vivo pharmacokinetic-pharmacodynamic analyses of 1’-acetoxychavicol acetae (ACA) against lung and prostate human tumors in rats - A.K.M. Mahmudul Haque, PhD (2015 - ongoing)
  • Acute, subchronic, chronic toxicity and toxicokineitc studies of 1’-acetoxychavicol acetae (ACA) - Yasir Osman Ali Abdalla, PhD(2015 - ongoing)
  • Factors influencing serum concentrations of adiponectin in obese or non-obese children - Nurulmazia Binti Abdul Rahimah, MMedical Sciences (2014 - ongoing)

 

Professional affiliations:

  • Malaysian Academy of Pharmacy - Internal auditor
  • Malaysian Pharmaceutical Society - Member
  • International Society of Pharmacometrics (ISoP) - Member
  • American Society for Clinical Pharmacology and Therapeutics (ASCPT) – Member

 

Academic Awards:

  • The School of Pharmacy Research Higher Degree Research Quality Awards, The School of Pharmacy, The University of Queensland, Queensland, Australia (2011)

 

Recent publications
(last 5 years – 2002 -2016)

2013

  1. Wei Zhao1,Florentia Kaguelidou, Vale Biran, Daolun Zhang, Karel Allegaert, Edmund V. Capparelli, Nick Holford, Toshimi Kimura, Yoke-Lin Lo, Jos steban Peris, Alison Thomson, John N. van den Anker, May Fakhoury, Evelyne Jacqz-Aigrain. External evaluation of population pharmacokinetic models of vancomycin in neonates: the transferability of published models to different clinical settings. British Journal of Clinical Pharmacology; 2013. 75(4): 1068-1080. [ISI IF 3.688, Q1; Scopus H-index 110, Q1].

 

2014

  1. Li-Ling Yeap, Yoke-Lin Lo. Rapid and simultaneous quantification of levetiracetam and its carboxylic metabolite in human plasma by liquid chromatography tandem mass spectrometry. PLoS ONE; 2014. 9(11): e111544. doi:10.1371/journal.pone.0111544. [ISI IF: 3.234, Q1; Scopus H-index 181, Q1].
  2. Li-Ling Yeap, Kheng-Seang Lim, Ching-Ching Ng, Amy Khor, Yoke-Lin Lo. Slow carbamazepine clearance in a non- adherent Malay epilepsy woman with thyrotoxicosis. Therapeutic Drug Monitoring; 2014. 36(1):3-9. [ISI IF: 2.376, Q2; Scopus H-index 77, Q2].
  3. Li-Ling Yeap, Kheng-Seang Lim, Yoke-Lin Lo, Mohd Zukiflee Abu Bakar, Chong-Tin Tan. Valproate-induced reversible sensorineural hearing loss, a case report with serial audiometry and pharmacokinetic modeling during a valproate rechallenge. Epileptic Disorders; 2014. 16(3):375-9. [ISI IF: 0.954, Q4; Scopus H-index 43, Q3]

 

2016

  1. SA Beshir, KH Chee, YL Lo. Factors Associated with Abrupt Discontinuation of Dabigatran therapy in patients with atrial fibrillation in a teaching hospital in Kuala Lumpur, Malaysia. International Journal of Clinical Pharmacy 2016; 38:1182-1190 DOI 10.1007/s11096-016-0350-1 [ISI IF: 1.339, Q4; Scopus H-index 41, Q1].
  2. Hann Juang Chai, Lik Voon Kiew, Yunni Chin, Anwar Norazit, Suzita Mohd Noor, Yoke Lin Lo, Chung Yeng Looi,Yeh Siang Lau, Tuck Meng Lim, Won Fen Wong, Nor Azizan Abdullah, Munavvar Zubaid Abdul Sattar, Edward J Johns, Zamri Chik, Lip Yong Chung. Renal targeting potential of a polymeric drug carrier poly-L-glutamic acid (PG) in normal and diabetic rats. International Journal of Nanomedicine. Accepted. [ISI IF: 4.320, Q1; Scopus H-index 64, Q1].

2013

  1. Wei Zhao1,Florentia Kaguelidou, Vale Biran, Daolun Zhang, Karel Allegaert, Edmund V. Capparelli, Nick Holford, Toshimi Kimura, Yoke-Lin Lo, Jos steban Peris, Alison Thomson, John N. van den Anker, May Fakhoury, Evelyne Jacqz-Aigrain. External evaluation of population pharmacokinetic models of vancomycin in neonates: the transferability of published models to different clinical settings. British Journal of Clinical Pharmacology; 2013. 75(4): 1068-1080. [ISI IF 3.688, Q1; Scopus H-index 110, Q1].

 

2014

  1. Li-Ling Yeap, Yoke-Lin Lo. Rapid and simultaneous quantification of levetiracetam and its carboxylic metabolite in human plasma by liquid chromatography tandem mass spectrometry. PLoS ONE; 2014. 9(11): e111544. doi:10.1371/journal.pone.0111544. [ISI IF: 3.234, Q1; Scopus H-index 181, Q1].

 

  1. Li-Ling Yeap, Kheng-Seang Lim, Ching-Ching Ng, Amy Khor, Yoke-Lin Lo. Slow carbamazepine clearance in a non- adherent Malay epilepsy woman with thyrotoxicosis. Therapeutic Drug Monitoring; 2014. 36(1):3-9. [ISI IF: 2.376, Q2; Scopus H-index 77, Q2].

 

  1. Li-Ling Yeap, Kheng-Seang Lim, Yoke-Lin Lo, Mohd Zukiflee Abu Bakar, Chong-Tin Tan. Valproate-induced reversible sensorineural hearing loss, a case report with serial audiometry and pharmacokinetic modeling during a valproate rechallenge. Epileptic Disorders; 2014. 16(3):375-9. [ISI IF: 0.954, Q4; Scopus H-index 43, Q3]

 

2016

  1. SA Beshir, KH Chee, YL Lo. Factors Associated with Abrupt Discontinuation of Dabigatran therapy in patients with atrial fibrillation in a teaching hospital in Kuala Lumpur, Malaysia. International Journal of Clinical Pharmacy 2016; 38:1182-1190 DOI 10.1007/s11096-016-0350-1 [ISI IF: 1.339, Q4; Scopus H-index 41, Q1].

 

  1. Hann Juang Chai, Lik Voon Kiew, Yunni Chin, Anwar Norazit, Suzita Mohd Noor, Yoke Lin Lo, Chung Yeng Looi,Yeh Siang Lau, Tuck Meng Lim, Won Fen Wong, Nor Azizan Abdullah, Munavvar Zubaid Abdul Sattar, Edward J Johns, Zamri Chik, Lip Yong Chung. Renal targeting potential of a polymeric drug carrier poly-L-glutamic acid (PG) in normal and diabetic rats. International Journal of Nanomedicine. Accepted. [ISI IF: 4.320, Q1; Scopus H-index 64, Q1].

 

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