FABIAN DAVAMANI

Designation/Title: Dr / Senior Lecturer
Department: Human Biology – Biomedical Science, School of Medical Science
Tel: 03-27317576
Fax: 03-86567229
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

 

Education and Training

Postdoctoral Fellow National Science Council, Taiwan -
Postdoctoral Associate National Institute of Immunology, India -
PhD Microbiology - Institute of Basic Medical Science. Madras University -
Masters University of Madras -

 

Research interests:

  • Cell and Molecular biology (Cloning, protein expression and purification, signaling)
  • Microbiology (Clinical isolation and related study, antimicrobial testing nano-formulations)
  • Microfluidic chip applications for research and diagnosis (Surface Plasmon based binding assay and diagnostics)

 

Research projects/grants:

  • RM 135,000 (2015 - 2018) Effect of madecassoside in reducing oxidative stress and blood glucose and in protecting the β-cells in streptozotocin-nicotinamide induced diabetes in rats. (Co- Investigator - FRGS)
  • RM 165,440 (2014 - 2017) Evaluation of the mechanism of action of lactoferricin B peptide in the inhibition of breast cancer. (Co- Investigator - FRGS)
  • RM 151,650 (2014 - 2017) Post-translational regulation of glutamine metabolism by acetylases and deacetylases in cancer cells under hypoxic conditions. (Co- Investigator - FRGS)
  • RM 121,120 (2014 - 2017) Does sun exposure affect PTH response to serum Vitamin D in Malaysian adults? (Co- Investigator - FRGS)
  • RM 819,902 (2014-2016) Biomarkers of polar and lower latitudes microbes in relation to heavy metal stress. (Co-Investigator - Antarctic Flagship Program)
  • RM 221,000 (2013-2015) Development of Novel Chitosan-flavonoids (Propolis Ethanolic Extract) Nanoformulations Against Enterococcus faecalis in the Root Canal Using Extracted Human Tooth Model. (Principal Investigator - ERGS)
  • RM 20,000 (2014 – 2015) Pharmacodynamics of Ellagic Acid on cardiac fibrosis in experimentally induced myocardial infraction. (Co-Investigator)
  • RM 20,000 (2013-14) Effect of HDGF (Hepatoma derived growth factor)-derived peptides on cell growth and apoptosis of cancer cell lines (Principal Investigator)
  • RM 20,000 (2013-14) Effect of bovine lactoferricin in the modulation of metalloproteases and tissue inhibitor of metalloproteases levels in metastatic and non-metastatic cell lines. (Co-Investigator)
  • RM 20,000 (2010-11) Identification of wound healing inhibitory components from snake venom. (Principal Investigator)
  • RM 20,000 (2010-11) Oncogene induced changes in migratory and proliferative properties of cells and alterations in intracellular signalling pathways.(Co-Investigator)
  • RM 20,000 (2011-12) Role of Malaysian snake venom component in disrupting the extra cellular matrix proteins and its effect on cancer cell invasions. (Investigator)
  • RM 20,000 (2011) Analysis of Cobra Snake-Venom Metalloproteinase (SVMP) Induced Alteration in Gene Expression in Fibroblast Cells. BMSc I01/09(08)2011 (Principal Investigator)
  • RM 20,000 (2011) Analysis of Env Oncogene-induced Gene Expression in Transformed 3T3 Cells. BMSc I01/09(07)2011 (Co-Investigator)
  • RM 20,000 (2012-13) Gene profiling of Malaysian cobra venom metalloproteases (MCVMP) treated HUVEC cells. (Principal Investigator)
  • RM 20,000 (2012-13) Study of the role of members of Ras/Akt pathways on the transformation ability of retroviral oncogene Env. (Co-Investigator)
  • RM 20,000 (2012-13) Wound Healing effect of Malaysian propolis and Brazilian red propolis on the connective tissue fibroblast cell lines and its genomic profiling in the healing process. (Co- Investigator)

 

Supervision of Postgraduates (MSc/PhD)
(Last 5 years – 2011-2015)

  • Mehru Nisha Muhamad Haneef (PhD candidate). Project Title: Determining the pattern and behavioural predictors of gastrointestinal parasitic infections in the Orang Asli using molecular techniques and classical methods of identification of gastrointestinal parasite. Researchers: Verasingam Kumarasamy, Stephen Ambu, Mak JW, Fabian Davamani. Start date: April 2011.
  • Peter Asaga Mac (PhD student). Project Title: Toxoplasma gondii MIC8 gene and their fusion protein as a DNA vaccine against Toxoplasmosis in a rat model. Researchers: Stephen Ambu, Fabian Davamani Susheela Devi Somanath. Start: 2011.
  • Dr. Abhishek Parolia. (PhD Candidate) Effectiveness of chitosan-flavonoids (propolis extract) nanoformulations against Enterococcus faecalis biofilms in the root canal using extracted human tooth model. Researchers: Fabian Davamani, Rajinikanth S. Start: 2014.
  • Ong Teik Hwa  (MSc Candidate): Development of a novel chitosan- flavonoids (propolis ethanolic extracts) nanoformulations against biofilm formed by Enterococcus faecalis.. Start: 2013. Researchers: Fabian Davamani, Ebenezer Chitra, Srinivasan Ramamurthy. Start: 2014.

Professional affiliations:

  • American society of Microbiology (ASM)
  • Indian Association of biomedical Scientists (IABMS)
  • Indian Association of Microbiologist (IAM)
  • School of Health Education (SHE)

 

Academic Awards:

  • The Lady Tata Memorial Trust – Junior Research Award - 1994
  • Council of Scientific and Industrial Research –Senior Research Award 1996
  • The Indian Association of Bio- Medical Scientist - Dr. Balakrishnan Memorial Award 1999.

 

Selected publications

  • Eu Gene Chua, Abhishek Parolia, Priya Ahlawat, Allan Pau, Fabian Davamani*.Antifungal effectiveness of various intracanal medicaments against Candida albicans: an ex-vivo study. BMC Oral Health, 2014; 14(1): 53. DOI: 10.1186/1472-6831-14-53.
  • Merlini Rajoo, Abhishek Parolia, Allan Pau, Fabian Davamani. The Role of Propolis in Inflammation and Orofacial Pain: A Review. Annual research and review in biology. 2014. 4(4) 651-664.
  • Tan, EL, Yew BK, Pichika RM, Davamani F, Gorajana A, Lim CL. Bioactive molecules: current trends in discovery, synthesis, delivery and testing. International e-Journal of Science, Medicine & Education 2013; 7(Suppl 1): 32-46.
  • Chia-Hui Wang*, Fabian Davamani*, Shih-Che Sue, Shao-Chen Lee, Po-long Wu, Fan-Mei Tang, Chiaho Shih, Tai-huang Huang and Wen-guey Wu. Cell surface heparan sulfates mediated internalization of PWWP/HATH domain of HDGF via macropinocytosis to fine-tune cell signaling process involved in and its effect on fibroblast cell migration. Biochem. J. 2011; (433) 127–138. (equal contribution)
  • Ebenezer Chitra, Yi-Wen Lin, Fabian Davamani, Kuang-Nan Hsiao, Charles Sia, Shih-Yang Hsieh, Olivia L Wei, Jen-Hao Chen and Yen-Hung Chow. Functional interaction between Env oncogene from Jaagsiekte sheep retrovirus and tumor suppressor Sprouty2. Retrovirology 2010, Aug 2; 7: 62.
  • Hong Hsiang Guan, King Siang Goh, Fabian Davamani, Po Long Wu, Yen Wei Huang, Jeyakanthan Jeyaraman, Wen guey Wu and Chun Jung Chen. Structures of two elapid snake venom metalloproteases with distinct activities highlight the disulfide patterns in the D domain of ADAMalysin family proteins. J Struct Biol. 2010; 169(3): 294-303.
 

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