CHYE SOI MOI

Designation/Title : Dr.
Department: Human Biology, Cell and Molecules
Tel: 03-27317220
Fax: 03-86567229
E-mail : This e-mail address is being protected from spambots. You need JavaScript enabled to view it

 

Education and Training

PhD
Kaohsiung Medical University
1998
MSc Kaohsiung Medical University 1994
BSc
Kaohsiung Medical University
1988

 

Research interests:

  • Immunodiagnostic of parasite infection
  • Investigation of apoptosis and carcinogenicity pathways of hair dye components
  • Investigation the molecular mechanism of melatonin in type 2 diabetes

 

Research projects/grants:

International (as Principal Investigator)

  • para-phenylenediamine induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in NRK52E cells.
    Fundamental Research Grant Scheme (FRGS), Ministry of Higher Education (MOHE),
    2011 – 2013 – Principal Researcher
  • Investigation of neurotrophic and neuroprotective effects of edible bird nest in Parkinson’s Disease Models
  • Fundamental Research Grant Scheme (FRGS), Ministry of Higher Education (MOHE),
    2012 – 2014 – Co-Researcher
  • Nucleolytic and anticancer properties of insulin-mimetic vanadium, zinc and cobalt complexes
    2009 – 2010 – Co-Researcher
    E-ScienceFund, MOSTI
  • Elevation of tumor necrosis factor-α by downregulation of protein kinase CK2 activity facilitates para-phenylenediamine induces NRK52E cell death through apoptosis and autophagy
    International Medical University Internal Grant
    2011- 2012- Principal Researcher
  • Involvement of PI3K/Akt-modulated expression of Bcl-2 and Bax in para-phenylenediamine induce apoptosis in NRK52E cells
    International Medical University Internal Grant
    2010- 2011- Principal Researcher
  • The effect of MAPK inhibitors on para-phenylenediamine induce Chang liver cell death in relation to reactive oxygen species
    International Medical University Internal Grant
    2010- 2011- Principal Researcher
  • Study the apoptosis pathway of para-phenylenediamine and it’s metabolite via ROS, caspase-8, -9 and -3/7
    International Medical University Internal Grant
    2009- 2010- Principal Researcher

 

Supervision of Postgraduates (MSc/PhD)
(Last 5 years – 2008-2012)

  • Reena A/P Kasi –MSc. (2011-Present)-Chief Supervisor
    phenylenediamine induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in NRK52E cells
  • Ong Li Chu- MSc. (2011-Present)-Co-Supervisor
    Systemic delivery of siRNA-based terapeutics using functionalised single-walled carbon nanotubes
  • Phoon Mei Ee- MSc. (2011-Present)-Co-Supervisor
    Investigation of neurotrophic and neuroprotective effects of edible bird nest in Parkinson’s Disease Models
  • Lai Maximilon- PhD (2012-Present)-Co-Supervisor
    The Role of Melatonin in Brain Iron Homeostasis and its Relevance to Parkinson’s Disease
  • Choo Heng Lungh- PhD (2010-Present)-Co-Supervisor
    Targeting the oncogenic function of Epstein-Barr Virus (EBV) proteins in nasopharyngeal carcinoma
  • Tan Boon Shing- MSc. (2010-Present)-Co-Supervisor
    Deciphering the mechanism of mutant p53 gain-of-function effects in human breast cancers

 

Professional affiliations:

  • Member, Malaysian Institute of Medical Laboratory Sciences (2007-)

 

Academic Awards:

  • ....

 

Recent publications
(last 5 years – 2008 -2012)

  • Leong CO, Chen SC, Tiong YL, Loh V F, Ng CH, Chye SM. 4-Chloro-1,2-phenylenediamine Induces Apoptosis in Mardin–Darby Canine Kidney Cells via Activation of Caspases. Environ Toxicol, 2012
  • Chin LF, Kong SM, Seng HL, Tiong YL, Neo KE, Maah MJ, Khoo AS, Ahmad M, Hor TS, Lee HB, San SL, Chye SM, Ng CH. [Zn(phen)(O,N,O)(H(2)O)] and [Zn(phen)(O,N)(H(2)O)] with O,N,O is 2,6-dipicolinate and N,O is L: -threoninate: synthesis, characterization, and biomedical properties. J Biol Inorg Chem. 2012 Jul 24.
  • Wu JC, Chye SM, Shih MK, Chen CH, Yang HL, Chen SC. Genotoxicity of dicrotophos, an organophosphorous pesticide, assessed with different assays in vitro. Environ Toxicol. 2012. 27(5):307-15
  • Tang LI, Ling AP, Koh RY, Chye SM, Voon KG. Screening of anti-dengue activity in methanolic extracts of medicinal plants. BMC Complement Altern Med. 2012; 12(1):3
  • Huang YC, Hung WC, Chye SM, Chen WT, Chai CY. para-Phenylenediamine-induced autophagy in human uroepithelial cell line mediated mutant p53 and activation of ERK signaling pathway. Toxicol In Vitro. 2011 25(8):1630-7.
  • Wu JC, Hseu YC, Tsai JS, Chen LC, Chye SM, Chen CH, Chen SC. Fenthion and terbufos induce DNA damage, the expression of tumor-related genes, and apoptosis in HepG2 cells. Environ Mol Mutagen, 2011. 52(7):529-37.
  • Chen SC, Chen CH, Tioh YL, Zhong PY, Lin YS, Chye SM. Apoptosis induced by DNA damage Para- phenylenediamine through oxidative stress and enhanced Caspase-8 and -9 activities in Mardin-Darby canine kidney cells. Toxicol in Vitro, 2010; 24: 1197–1202.
  • Chye SM, Hseu YC, Liang SH, Chen CH, Chen SC. Single Strand DNA Breaks in human lymphocytes exposed to para-Phenylenediamine and its Derivatives Bull Environ Contam Toxicol, 2008; 80(1):58-62.
  • Chen SC, Chen CH, Chern CL, Hsu LS, Huang YC, Chye SM. p-phenylenediamine induces p53-mediated apoptosis in Mardin-Darvey canine Kidney cells. Toxicol in Vitro, 2006; 20: 801-807.
  • Wang SM, Chye SM, Liu RH, Lewis RJ, Canfield DV. Characteristics of Commonly Abused Amphetamines with Sequential Derivatization at Two Active Sites. Forensic Sci Int, 2006; 161: 97-118.
  • Wong CH, Liu TZ, Chye SM, Lu FJ, Liu YC, Lin ZC, Chen CH. Sevoflurane- induced oxidative stress and cellular injury in human peripheral polymorphonuclear neutrophils. Food Chem Toxicol, 2006; 44: 1399-1407.


 

 

 

 

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